Molekula
Leucovorin calcium salt
Supplying 4,500+ customers in over 80 countries
ISO 9001:2015 & ISO 14001:2015 certified · Supplying laboratories and industry since 2000 · Listed pack sizes are a starting point — we manufacture, source and repack to the quantity you need
Leucovorin calcium salt is a synthetic folic acid derivative used primarily as a rescue agent in high-dose methotrexate chemotherapy to counteract toxicity, and also in the treatment of megaloblastic anemia. This compound is a calcium salt of leucovorin, essential for DNA synthesis and cellular repair. CAS 6035-45-6, molecular formula C20H31CaN7O12, molecular weight 601.58 g/mol. Store at -15 to -20°C. Signal word: Danger. Molekula supplies leucovorin calcium salt from research to bulk quantities with full documentation and ISO 9001:2015 traceability.
Example image for illustration only. Other packaging and pack sizes are available.
Pricing & pack sizes
Pack sizes & pricing
Pricing on request — packs available from research to bulk quantities.
Need a different quantity or pack?
Tell us how much you need and when — drums, IBCs, sacks or a one-off bulk lot. We'll manufacture or source it and come back with a price.
Prices exclude VAT/sales tax and shipping.
Specifications
| Property | Value |
|---|---|
| Appearance | White to off-white solid |
Storage & handling
| Property | Value |
|---|---|
| Storage Temperature | -15 to -20 °C |
| Acidity | Neutral |
Identification
| Property | Value |
|---|---|
| SKU | 25680865 |
| CAS Number | 6035-45-6 |
| IUPAC Name | calcium;(2S)-2-[[4-[(2-amino-5-formyl-4-oxo-3,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]pentanedioate;pentahydrate |
| Molecular Formula | C20H31CaN7O12 |
| Molecular Weight | 601.577839999999 |
| Exact Mass | 601.1657 |
| SMILES | C1C(N(C2=C(N1)N=C(NC2=O)N)C=O)CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-].O.O.O.O.O.[Ca+2] |
| InChIKey | NPPBLUASYYNAIG-ZIGBGYJWSA-L |
| InChI | InChI=1S/C20H23N7O7.Ca.5H2O/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30;;;;;;/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32);;5*1H2/q;+2;;;;;/p-2/t12?,13-;;;;;;/m0....../s1 |
| PubChem CID | 135802074 |
| REACH Code | Y110 |
| HTS Code | 2936.29.2000 |
| Tariff Code | 2936290000 |
Safety & GHS
-
Health Hazard
GHS07
-
Serious Health Hazard
GHS08
Hazard statements
- H315 Causes skin irritation
- H317 May cause an allergic skin reaction
- H319 Causes serious eye irritation
- H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled
- H335 May cause respiratory irritation
Precautionary statements
- P260 Do not breathe dust/fume/gas/mist/vapours/spray
- P280 Wear protective gloves/protective clothing/eye protection/face protection
- P284 Wear respiratory protection
- P302+352 IF ON SKIN: Wash with soap and water
- P304+340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing
- P305+351+338 IF IN EYES: Rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing
Documents
Safety Data Sheets (SDS)
Available in English, French, German, Italian, Portuguese, Spanish.
Certificate of Analysis (CoA) by batch
Enter a lot or batch number to retrieve the CoA for that specific batch. We can generate one from spec data if no PDF is on file.
Synonyms
- Calcium folinatc
- Calcium folinate pentahydrate
- Folinic acid (calcium salt pentahydrate)
- FOLINIC ACID CALCIUM PENTAHYDRATE
- Leucovorin calcium hydrate
- Leucovorin calcium pentahydrate
- Leucovorin calcium salt pentahydrate
- Wellcovorin
Frequently asked questions
What is leucovorin calcium used for?
Leucovorin calcium is primarily used in chemotherapy to reduce the toxicity and side effects of methotrexate, as well as in the treatment of megaloblastic anemia caused by folate deficiency.
What is the chemical formula and molecular weight of leucovorin calcium?
The chemical formula is **C<sub>20</sub>H<sub>31</sub>CaN<sub>7</sub>O<sub>12</sub>**, and the molecular weight is **601.58 g/mol**.
How should leucovorin calcium be stored?
Store leucovorin calcium at **-15 to -20°C** to maintain stability and potency.
What grades or purity levels are available for leucovorin calcium?
Molekula supplies leucovorin calcium in **pharmaceutical-grade purity** (typically ≥98% HPLC).
Can Molekula supply leucovorin calcium in bulk quantities?
Yes, we offer leucovorin calcium in bulk, with flexible packaging options (e.g., drums, bags) for large-volume orders.
What documentation comes with a leucovorin calcium order?
Each order includes a **Certificate of Analysis (CoA)**, **Material Safety Data Sheet (MSDS)**, and **batch-specific documentation** for traceability.
Ready to order or need a custom pack?
Tell us the product, grade, and quantity — Molekula usually responds within one working day with pricing and lead time.