Knowledge hub
Articles from the Molekula editorial team
Coverage of chemistry, regulatory updates, methods, supply-chain insight, and product spotlights. New articles published daily.
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Regulatory
Regulatory outlook for nanocellulose excipients under FDA’s 2026 nanomaterial framework
The FDA’s 2026 nanomaterial framework introduces explicit requirements for nanocellulose excipients, including detailed physicochemical characterisation, toxicology testing, and alignment with existing GMP standards. Compliance will rely on robust data packages, early engagement with the agency, and coordination with international guidelines such as REACH and ISO.
Nov 10, 2026 · 6 min read -
Product-spotlight
Buyer’s guide to high‑purity fluorinated bicyclic scaffolds for PET imaging agents
High‑purity fluorinated bicyclic scaffolds are essential for reliable PET radiotracers. Selecting the right scaffold involves assessing fluorine‑18 incorporation efficiency, stereochemical integrity, regulatory compliance (ISO, REACH), and analytical characterisation (NMR, HPLC, GC‑MS). Molekula offers GMP‑grade options with full CoA and SDS documentation.
Nov 9, 2026 · 5 min read -
Supplier-news
Supply‑chain resilience for isotopically labelled nucleotides during geopolitical tensions in 2026
Isotopically labelled nucleotides remain essential for molecular biology, but 2026 geopolitical tensions have disrupted raw‑material flows, increased lead times to 8–12 weeks and raised costs by up to 35 %. Diversified sourcing, strategic stockpiling and robust quality‑control pipelines are key to maintaining supply‑chain resilience.
Nov 8, 2026 · 5 min read -
Regulatory
Navigating the Updated ICH Q13 Guidelines for Impurity Profiling in Small‑Molecule APIs
The ICH Q13 guideline, revised in 2022, sets a risk‑based framework for impurity profiling of small‑molecule active pharmaceutical ingredients (APIs). It clarifies the definition of impurity profiling, outlines analytical strategies, and integrates toxicological thresholds to support regulatory submissions and product quality.
Nov 7, 2026 · 5 min read -
Regulatory
Assessing the impact of EU Green Deal incentives on biodegradable surfactant procurement
The EU Green Deal provides financial incentives and regulatory targets that lower the cost of biodegradable surfactants, increase supplier competition, and drive procurement policies toward greener alternatives. Key effects include reduced price volatility, expanded product ranges, and tighter compliance requirements for REACH and circular‑economy standards.
Nov 6, 2026 · 4 min read -
Method
Implementing Continuous Flow Photoredox Reactors: Reagent Selection and Safety Considerations
Continuous flow photoredox reactors combine light‑driven catalysis with the advantages of flow chemistry. Successful implementation hinges on choosing photostable catalysts, compatible solvents, and appropriate additives, while rigorously managing light exposure, pressure, and thermal hazards. Safety protocols and equipment design are essential to mitigate risks and ensure reproducible results.
Nov 5, 2026 · 7 min read -
Supplier-news
Strategic sourcing of high‑purity scandium triflate catalysts amid US export restrictions
US export controls on rare‑earth compounds, including scandium triflate, limit direct procurement from American suppliers. Companies can mitigate risk by diversifying supply chains, qualifying alternative grades, and implementing robust quality‑control protocols. Early engagement with compliant manufacturers, such as Molekula, helps maintain catalyst availability for fine‑chemical and biopharma processes.
Nov 4, 2026 · 5 min read -
Method-comparison
Evaluating Emerging Bio‑Based Polyether Solvents for Peptide Coupling under REACH 2026
Bio‑based polyether solvents are being assessed as greener alternatives for peptide coupling. Key parameters include polarity, boiling point, REACH‑2026 compliance, and compatibility with common coupling reagents. Data show comparable yields to traditional solvents while reducing hazardous classifications under GHS.
Nov 3, 2026 · 5 min read -
Supplier-news
Dual sourcing strategies for single‑supplier reagents: qualification costs versus continuity benefits
Dual sourcing mitigates supply risk by qualifying a secondary supplier alongside the primary source. While qualification incurs additional analytical work—typically 1–3 weeks and £500–£2 000 per reagent—the continuity benefits can prevent costly downtime, maintain batch integrity and protect regulatory compliance.
Nov 2, 2026 · 5 min read -
Supplier-news
Protecting groups in oligonucleotide synthesis: phosphoramidite quality and supply constraints in 2026
Protecting groups such as DMTr, TBDMS, and Ace are standard in solid‑phase oligonucleotide synthesis. Phosphoramidite purity directly influences coupling yields and impurity profiles, while 2026 has seen tighter raw‑material supplies, longer lead times and price volatility due to raw‑chemical shortages and regulatory bottlenecks.
Nov 1, 2026 · 6 min read -
Method-comparison
Copper‑free click chemistry reagents for bioconjugation: DBCO, BCN and tetrazine selection guide
Copper‑free click reagents DBCO, BCN and tetrazine each offer distinct kinetics, stability and functional‑group compatibility. DBCO provides reliable SPAAC with azides (k≈10^2 M⁻¹ s⁻¹), BCN is smaller but slower, while tetrazine–TCO ligation is the fastest (k≈10^4‑10^5 M⁻¹ s⁻¹) but requires strained alkene partners. Choose based on reaction speed, steric constraints and biological context.
Oct 31, 2026 · 6 min read -
Product-spotlight
Chiral Resolving Agents and Auxiliaries: A Buyer’s Guide to Tartaric, Mandelic and Camphorsulfonic Acids
Tartaric, mandelic and camphorsulfonic acids are widely used chiral resolving agents and auxiliaries. Their effectiveness depends on acidity, solubility, stereochemical rigidity and regulatory status. This guide summarises key properties, comparative performance, handling requirements and purchasing considerations for chemists in fine‑chemical, biotech and pharmaceutical settings.
Oct 30, 2026 · 5 min read