Molekula
TRIS (Tris(hydroxymethyl)aminomethane)
Supplying 4,500+ customers in over 80 countries
ISO 9001:2015 & ISO 14001:2015 certified · Supplying laboratories and industry since 2000 · Listed pack sizes are a starting point — we manufacture, source and repack to the quantity you need
TRIS (Tris(hydroxymethyl)aminomethane) is a widely used buffering agent and pH stabilizer in biochemical research, pharmaceutical formulations, and molecular biology applications, including electrophoresis and enzyme assays. It is also employed in cell culture media and as a reagent in chemical synthesis. This chemical has a CAS number of 77-86-1, with the molecular formula NH2C(CH2OH)3 and a molecular weight of 121.14. It is typically stored at ambient conditions and carries a signal word of Warning for safety classification. Molekula supplies TRIS from research to bulk quantities with full documentation and ISO 9001:2015 traceability.
Example image for illustration only. Other packaging and pack sizes are available.
Often bought together
Pricing & pack sizes
These pack sizes aren't a limit. Molekula manufactures, sources and repacks to order — if you need 500 kg and only see 1 kg listed, . We quote from grams to multi-tonne.
Need a different size? Add the nearest pack and change the size in your basket — we price it at the same rate per unit.
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500 g — $123.50 per pack
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1 kg — $192.70 per pack
Need a different quantity or pack?
Tell us how much you need and when — drums, IBCs, sacks or a one-off bulk lot. We'll manufacture or source it and come back with a price.
Prices exclude VAT/sales tax and shipping.
Specifications
| Property | Value |
|---|---|
| Appearance | White crystalline powder |
| Assay/Purity | ≥ 99.0% |
| Melting Point | 168 - 172°C |
| Water | ≤ 0.2% |
| Heavy metals | ≤ 5ppm |
| pH | 10.0 to 11.5, (5% aqueous) |
| Loss on Drying | ≤ 1.0% |
| Residue on Ignition | ≤ 0.1% |
| Iron (Fe) | ≤ 1ppm |
| Identification (IR) | Conforms to Reference |
Storage & handling
| Property | Value |
|---|---|
| Storage Temperature | Ambient |
| Acidity | Base |
Identification
| Property | Value |
|---|---|
| SKU | 90004862 |
| CAS Number | 77-86-1 |
| Molecular Formula | NH2C(CH2OH)3 |
| Molecular Weight | 121.14 |
| SMILES | C(C(CO)(CO)N)O |
| REACH Code | Y113 |
| TSCA Listed | Yes |
| HTS Code | 29221996 |
| Tariff Code | 2922190090 |
Safety & GHS
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Health Hazard
GHS07
Hazard statements
- H315 Causes skin irritation
- H319 Causes serious eye irritation
- H335 May cause respiratory irritation
Precautionary statements
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray
- P280 Wear protective gloves/protective clothing/eye protection/face protection
- P305+351+338 IF IN EYES: Rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing
- P308+313 IF exposed or concerned: Get medical advice/attention
Documents
Safety Data Sheets (SDS)
Available in English, French, German, Italian, Portuguese, Spanish.
Certificate of Analysis (CoA) by batch
Enter a lot or batch number to retrieve the CoA for that specific batch. We can generate one from spec data if no PDF is on file.
Synonyms
No alternate names recorded for this product.
Frequently asked questions
What is TRIS (Tris(hydroxymethyl)aminomethane) commonly used for?
TRIS is widely used as a buffer in biochemical and molecular biology applications, such as in PCR, gel electrophoresis, and cell culture media, due to its effective buffering range of about pH 7 to 9 (pKa approximately 8.1 at 25 °C). Its pH is temperature-dependent, falling by roughly 0.03 pH units per °C rise, so TRIS buffers should be pH-adjusted at the temperature at which they will be used.
What is the chemical formula and molecular weight of TRIS?
The chemical formula of TRIS is NH₂C(CH₂OH)₃, and its molecular weight is 121.14 g/mol.
How should TRIS be stored?
TRIS should be stored at ambient temperature in a tightly sealed container, away from moisture and strong oxidizing agents.
What grades of TRIS does Molekula supply?
Molekula supplies analytical grade and biochemical grade TRIS, suitable for laboratory and research applications.
Can Molekula supply TRIS in bulk quantities?
Yes, Molekula can supply TRIS in bulk, with quantities tailored to meet customer requirements—please contact us for pricing and availability.
What documentation comes with a TRIS order?
Each TRIS order includes a Certificate of Analysis (CoA), Material Safety Data Sheet (MSDS), and batch-specific documentation for traceability.
Ready to order or need a custom pack?
Tell us the product, grade, and quantity — Molekula usually responds within one working day with pricing and lead time.