Molekula
TRIS hydrochloride
Supplying 4,500+ customers in over 80 countries
ISO 9001:2015 & ISO 14001:2015 certified · Supplying laboratories and industry since 2000 · Listed pack sizes are a starting point — we manufacture, source and repack to the quantity you need
TRIS hydrochloride is a buffering agent commonly used in biochemical and molecular biology applications, particularly in nucleic acid and protein purification. Beyond the laboratory, it serves as an intermediate for surfactants and pharmaceuticals and as an emulsifier and stabilizing agent in formulations such as cosmetic creams and lotions. It maintains stable pH in aqueous solutions. Available with CAS number 1185-53-1, molecular formula NH2C(CH2OH)3 · HCl, and molecular weight 157.60 g/mol. Stored at ambient temperature. Signal word: Warning. Molekula supplies TRIS hydrochloride from research to bulk quantities with full documentation and ISO 9001:2015 traceability.
Example image for illustration only. Other packaging and pack sizes are available.
Often bought together
Pricing & pack sizes
These pack sizes aren't a limit. Molekula manufactures, sources and repacks to order — if you need 500 kg and only see 1 kg listed, . We quote from grams to multi-tonne.
Need a different size? Add the nearest pack and change the size in your basket — we price it at the same rate per unit.
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100 g — £34.10 per pack ex VAT · £40.92 inc. VAT
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500 g — £85.00 per pack ex VAT · £102.00 inc. VAT
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1 kg — £132.50 per pack ex VAT · £159.00 inc. VAT
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5 kg — £463.40 per pack ex VAT · £556.08 inc. VAT
Need a different quantity or pack?
Tell us how much you need and when — drums, IBCs, sacks or a one-off bulk lot. We'll manufacture or source it and come back with a price.
Prices exclude VAT/sales tax and shipping.
Specifications
| Property | Value |
|---|---|
| Appearance | White crystalline powder |
| Melting Point | 150 - 155°C |
| Water | ≤0.5% |
| Identification | Conforms to reference |
| pH | 4.2 - 5 |
| Content | ≥99% |
| Iron (Fe) | ≤5ppm |
| Trace Metal Analysis | ≤5ppm |
Storage & handling
| Property | Value |
|---|---|
| Storage Temperature | Ambient |
| Acidity | Acid |
For research use only. Not for human use.
Identification
| Property | Value |
|---|---|
| SKU | 14689173 |
| CAS Number | 1185-53-1 |
| IUPAC Name | 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydrochloride |
| EC Number | 214-684-5 |
| Molecular Formula | NH2C(CH2OH)3 · HCl |
| Molecular Weight | 157.60 |
| Exact Mass | 157.0506 |
| SMILES | C(C(CO)(CO)N)O.Cl |
| InChIKey | QKNYBSVHEMOAJP-UHFFFAOYSA-N |
| InChI | InChI=1S/C4H11NO3.ClH/c5-4(1-6,2-7)3-8;/h6-8H,1-3,5H2;1H |
| PubChem CID | 93573 |
| REACH Code | Y110 |
| TSCA Listed | Yes |
| HTS Code | 29221996 |
| Tariff Code | 2922190090 |
Safety & GHS
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Health Hazard
GHS07
Hazard statements
- H315 Causes skin irritation
- H319 Causes serious eye irritation
- H335 May cause respiratory irritation
Precautionary statements
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray
- P280 Wear protective gloves/protective clothing/eye protection/face protection
- P302+352 IF ON SKIN: Wash with soap and water
- P305+351+338 IF IN EYES: Rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing
- P332+313 IF skin irritation occurs: Get medical advice/attention
- P337+313 If eye irritation persists get medical advice/attention
Documents
Safety Data Sheets (SDS)
Available in English, French, German, Italian, Spanish.
Certificate of Analysis (CoA) by batch
Enter a lot or batch number to retrieve the CoA for that specific batch. We can generate one from spec data if no PDF is on file.
Synonyms
- 1,3-Propanediol, 2-amino-2-(hydroxymethyl)-, hydrochloride
- 2-Amino-2-(hydroxymethyl)propane-1,3-diol hydrochloride
- Tris chloride
- TRIS HCl
- Tris hydrochloride buffer
- Tris(hydroxymethyl)aminomethane hydrochloride
- Trizma hydrochloride
- Trometamol hydrochloride
- Tromethamine HCl
- Tromethamine hydrochloride
Frequently asked questions
What is TRIS hydrochloride used for?
TRIS hydrochloride is commonly used as a buffer in biochemical and molecular biology applications, particularly in electrophoresis and enzyme assays.
What is the chemical formula and molecular weight of TRIS hydrochloride?
The formula is NH2C(CH2OH)3 · HCl with a molecular weight of 157.60 g/mol.
How should TRIS hydrochloride be stored?
It should be stored at ambient temperature, protected from moisture and light.
What grade of TRIS hydrochloride is available?
Molekula supplies TRIS hydrochloride in high-purity grade suitable for laboratory and research use.
Can Molekula supply TRIS hydrochloride in bulk?
Yes, Molekula can supply TRIS hydrochloride in bulk quantities—please contact our sales team for pricing and availability.
What documentation comes with a TRIS hydrochloride order?
Each order includes a Certificate of Analysis (CoA) and Safety Data Sheet (SDS) with the shipment.
Ready to order or need a custom pack?
Tell us the product, grade, and quantity — Molekula usually responds within one working day with pricing and lead time.