Molekula
Trimethylsilyl(trifluoromethane)
Supplying 4,500+ customers in over 80 countries
ISO 9001:2015 & ISO 14001:2015 certified · Supplying laboratories and industry since 2000 · Listed pack sizes are a starting point — we manufacture, source and repack to the quantity you need
Trimethylsilyl(trifluoromethane), also known as (trifluoromethyl)trimethylsilane, TMS-CF3 or the Ruppert-Prakash reagent, is a reactive organosilicon compound primarily used as a nucleophilic trifluoromethylating reagent in organic synthesis, particularly for adding CF3 groups to aldehydes, ketones and imines under fluoride activation. This chemical has a CAS number of 81290-20-2, a molecular formula of (CH3)3SiCF3, and a molecular weight of 142.19 g/mol. It must be stored between 2 to 8°C and is classified with the signal word "Danger" due to its hazardous properties. Molekula supplies Trimethylsilyl(trifluoromethane) from research to bulk quantities with full documentation and ISO 9001:2015 traceability.
Example image for illustration only. Other packaging and pack sizes are available.
Pricing & pack sizes
Pack sizes & pricing
Pricing on request — packs available from research to bulk quantities.
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Specifications
| Property | Value |
|---|---|
| Purity | 99% min |
Storage & handling
| Property | Value |
|---|---|
| Storage Temperature | 2 to 8 °C |
| Flash Point | -17 °C |
| Transport Class | 3 |
| Packing Group | II |
| Acidity | Acid |
Identification
| Property | Value |
|---|---|
| SKU | 18123773 |
| CAS Number | 81290-20-2 |
| IUPAC Name | trimethyl(trifluoromethyl)silane |
| Molecular Formula | (CH3)3SiCF3 |
| Molecular Weight | 142.19 |
| Exact Mass | 142.0426 |
| SMILES | C[Si](C)(C)C(F)(F)F |
| InChIKey | MWKJTNBSKNUMFN-UHFFFAOYSA-N |
| InChI | InChI=1S/C4H9F3Si/c1-8(2,3)4(5,6)7/h1-3H3 |
| PubChem CID | 552549 |
| UN Number | UN1993 |
| REACH Code | Y110 |
| Tariff Code | 2931900090 |
Safety & GHS
-
Flammable
GHS02
-
Health Hazard
GHS07
Hazard statements
- H225 Highly flammable liquid and vapour
- H261 In contact with water releases flammable gas
- H315 Causes skin irritation
- H319 Causes serious eye irritation
- H335 May cause respiratory irritation
Precautionary statements
- P210 Keep away from heat/sparks/open flames/hot surfaces - No smoking
- P232 Protect from moisture
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray
- P280 Wear protective gloves/protective clothing/eye protection/face protection
- P305+351+338 IF IN EYES: Rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing
- P308+313 IF exposed or concerned: Get medical advice/attention
Documents
Safety Data Sheets (SDS)
Available in English, French, German, Italian, Spanish.
Certificate of Analysis (CoA) by batch
Enter a lot or batch number to retrieve the CoA for that specific batch. We can generate one from spec data if no PDF is on file.
Synonyms
- (Trifluoromethyl)trimethylsilane
- (Trifluoromethyl)trimethylsilane;TMS-CF3
- CF3SiMe3
- Ruppert-Prakash Reagent
- Ruppert's Reagent
- Silane, trimethyl(trifluoromethyl)-
- TFMTMS
- TMS-CF3
- Trifluoro(trimethylsilyl)methane
- Trimethyl(trifluoromethyl)silane
Frequently asked questions
What is Trimethylsilyl(trifluoromethane) used for?
This compound, the Ruppert-Prakash reagent, is primarily used as a nucleophilic trifluoromethylating reagent in organic synthesis, for example to add CF3 groups to aldehydes, ketones and imines under fluoride activation.
What is the molecular formula and molecular weight of Trimethylsilyl(trifluoromethane)?
The molecular formula is (CH₃)₃SiCF₃, and the molecular weight is 142.19 g/mol.
How should Trimethylsilyl(trifluoromethane) be stored?
Store at 2–8°C in a tightly sealed container, away from moisture, heat, and incompatible substances.
What grade or purity is available for this product?
Molekula supplies this product in analytical/HPLC-grade purity (typically ≥99%).
Can Molekula supply Trimethylsilyl(trifluoromethane) in bulk quantities?
Yes, we can provide bulk quantities upon request—contact our sales team for pricing and availability.
What documentation comes with an order of this product?
Each order includes a Certificate of Analysis (CoA), Material Safety Data Sheet (MSDS), and batch-specific documentation for traceability.
Ready to order or need a custom pack?
Tell us the product, grade, and quantity — Molekula usually responds within one working day with pricing and lead time.