Molekula
Trifluoromethanesulfonic anhydride (Triflic anhydride)
Supplying 4,500+ customers in over 80 countries
ISO 9001:2015 & ISO 14001:2015 certified · Supplying laboratories and industry since 2000 · Listed pack sizes are a starting point — we manufacture, source and repack to the quantity you need
Trifluoromethanesulfonic anhydride, or triflic anhydride, is a highly reactive reagent widely used in organic synthesis for introducing trifluoromethanesulfonyl groups, enabling the preparation of aryl and vinyl triflates from phenols and ketones, dehydrations, and activation of carboxylic acids. This colorless to pale yellow liquid is a powerful sulfonylating agent with exceptional stability under anhydrous conditions. Catalogue details: CAS 358-23-6, molecular formula (CF₃SO₂)₂O, molecular weight 282.14 g/mol. Store at ambient temperature in a dry, inert atmosphere. Hazard classification: Danger (corrosive, toxic). Molekula supplies triflic anhydride from research to bulk quantities with full documentation and ISO 9001:2015 traceability.
Example image for illustration only. Other packaging and pack sizes are available.
Pricing & pack sizes
Pack sizes & pricing
Pricing on request — packs available from research to bulk quantities.
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Specifications
| Property | Value |
|---|---|
| Appearance | Clear colourless liquid |
| Assay | ≥99.0% |
| Fluoride (F-) | ≤100ppm |
| CF3SO3H | ≤0.5% |
Storage & handling
| Property | Value |
|---|---|
| Storage Temperature | Ambient |
| Transport Class | 5.1 (8) |
| Packing Group | II |
| Acidity | Acid |
Identification
| Property | Value |
|---|---|
| SKU | 34608611 |
| CAS Number | 358-23-6 |
| Molecular Formula | (CF3SO2)2O |
| Molecular Weight | 282.14 |
| SMILES | O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F |
| UN Number | UN3098 |
| REACH Code | Y110 |
| TSCA Listed | Yes |
| HTS Code | 29049950 |
| Tariff Code | 2904990090 |
Safety & GHS
-
Oxidizing
GHS03
-
Corrosive
GHS05
-
Health Hazard
GHS07
Hazard statements
- EUH014 Reacts violently with water
- H272 May intensify fire; oxidizer
- H302 Harmful if swallowed
- H314 (sub cat. 1B) Causes severe skin burns and eye damage
- H335 May cause respiratory irritation
Precautionary statements
- P210 Keep away from heat/sparks/open flames/hot surfaces - No smoking
- P260 Do not breathe dust/fume/gas/mist/vapours/spray
- P280 Wear protective gloves/protective clothing/eye protection/face protection
- P302+352 IF ON SKIN: Wash with soap and water
- P305+351+338 IF IN EYES: Rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing
- P310 Immediately call a POISON CENTER or doctor/physician
Documents
Safety Data Sheets (SDS)
Available in English, French, German, Italian, Spanish.
Certificate of Analysis (CoA) by batch
Enter a lot or batch number to retrieve the CoA for that specific batch. We can generate one from spec data if no PDF is on file.
Synonyms
No alternate names recorded for this product.
Frequently asked questions
What is trifluoromethanesulfonic anhydride (triflic anhydride) commonly used for?
Triflic anhydride is primarily used as a strong sulfonylating agent in organic synthesis, particularly for activating carboxylic acids, alcohols, and amines in peptide coupling, esterification, and other reactions requiring high reactivity.
What is the chemical formula and molecular weight of triflic anhydride?
The chemical formula is (CF₃SO₂)₂O, and the molecular weight is 282.14 g/mol.
How should triflic anhydride be stored?
Store triflic anhydride in a cool, dry place at ambient temperature, away from moisture and incompatible materials. Use airtight containers with proper sealing.
What purity grades of triflic anhydride does Molekula supply?
Molekula supplies triflic anhydride in high-purity grades (≥98% purity), suitable for research and industrial applications. Contact us for specific grade details.
Can Molekula supply triflic anhydride in bulk quantities?
Yes, Molekula can supply triflic anhydride in bulk quantities—please inquire for minimum order quantities (MOQs) and packaging options.
What documentation comes with an order of triflic anhydride?
Each order includes a Certificate of Analysis (CoA), Material Safety Data Sheet (MSDS), and batch-specific documentation for traceability and compliance.
Ready to order or need a custom pack?
Tell us the product, grade, and quantity — Molekula usually responds within one working day with pricing and lead time.