Molekula
Trifluoroacetic acid for protein analysis
Supplying 4,500+ customers in over 80 countries
ISO 9001:2015 & ISO 14001:2015 certified · Supplying laboratories and industry since 1999 · Listed pack sizes are a starting point — we manufacture, source and repack to the quantity you need
Trifluoroacetic acid (TFA) is a strong synthetic fluorinated carboxylic acid widely used in protein and peptide analysis for mass spectrometry sample preparation, HPLC mobile phases, and protein precipitation. It enhances ionization efficiency and improves chromatographic separation due to its volatility and acidity. Beyond analysis, it serves as a strong acid reagent, solvent and catalyst in organic synthesis, including the manufacture of other organic chemicals. Catalogue details: CAS 76-05-1, molecular formula CF₃COOH, molecular weight 114.02 g/mol. Store at ambient conditions. Hazard classification: Danger (causes severe skin burns and serious eye damage, harmful if inhaled, harmful to aquatic life with long lasting effects). Molekula supplies Trifluoroacetic acid from research to bulk quantities with full documentation and ISO 9001:2015 traceability.
Example image for illustration only. Other packaging and pack sizes are available.
Pricing & pack sizes
On backorder — expected to ship by 26 November 2026
These pack sizes aren't a limit. Molekula manufactures, sources and repacks to order — if you need 500 kg and only see 1 kg listed, . We quote from grams to multi-tonne.
Need a different size? Add the nearest pack and change the size in your basket — we price it at the same rate per unit.
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100 g — £38.90 per pack ex VAT · £46.68 inc. VAT
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500 g — £107.40 per pack ex VAT · £128.88 inc. VAT
Need a different quantity or pack?
Tell us how much you need and when — drums, IBCs, sacks or a one-off bulk lot. We'll manufacture or source it and come back with a price.
Prices exclude VAT/sales tax and shipping.
Specifications
| Property | Value |
|---|---|
| Appearance | Clear colourless liquid |
| Assay/Purity | >99% |
Storage & handling
| Property | Value |
|---|---|
| Storage Temperature | Ambient |
| Flash Point | 100 °C |
| Transport Class | 8 |
| Packing Group | I |
| Acidity | Acid |
Literature values
Published physical properties of the substance, not batch specifications.
| Property | Value |
|---|---|
| Appearance | Liquid |
| Odour | Sharp biting odor |
| Melting Point | -15 °C |
| Boiling Point | 72 °C |
| Density | 1.5 (relative, water = 1) |
| Vapour Pressure | 11 kPa at 20 °C |
| Refractive Index | 1.2850 |
| pKa | pKa = 0.3 |
Source: PubChem CID 6422 (HSDB, ICSC)
Identification
| Property | Value |
|---|---|
| SKU | 11412584 |
| CAS Number | 76-05-1 |
| IUPAC Name | 2,2,2-trifluoroacetic acid |
| EC Number | 200-929-3 |
| Molecular Formula | CF3COOH |
| Molecular Weight | 114.02 |
| Exact Mass | 113.9929 |
| SMILES | C(=O)(C(F)(F)F)O |
| InChIKey | DTQVDTLACAAQTR-UHFFFAOYSA-N |
| InChI | InChI=1S/C2HF3O2/c3-2(4,5)1(6)7/h(H,6,7) |
| PubChem CID | 6422 |
| UN Number | UN2699 |
| REACH Code | Y110 |
| TSCA Listed | Yes |
| HTS Code | 29159018 |
| Tariff Code | 2915909043 |
Safety & GHS
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Corrosive
GHS05
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Health Hazard
GHS07
Hazard statements
- H314 (sub cat. 1A) Causes severe skin burns and eye damage
- H318 Causes serious eye damage
- H332 Harmful if inhaled
- H412 Harmful to aquatic life with long lasting effects
Precautionary statements
- P273 Avoid release to the environment
- P280 Wear protective gloves/protective clothing/eye protection/face protection
- P303+361 IF ON SKIN (or hair): Remove immediately all contaminated clothing. Rinse with water/shower
- P304+340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing
- P305+351+338 IF IN EYES: Rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing
Documents
Safety Data Sheets (SDS)
Available in English, French, German, Italian, Spanish.
Certificate of Analysis (CoA) by batch
Enter a lot or batch number to retrieve the CoA for that specific batch. We can generate one from spec data if no PDF is on file.
Quality certificates
Molekula Group is certified to ISO 9001:2015 (quality) and ISO 14001:2015 (environmental management), audited by a UKAS-accredited body. Both certificates are valid to 17 May 2028.
Synonyms
No alternate names recorded for this product.
Frequently asked questions
What is trifluoroacetic acid (TFA) used for in protein analysis?
TFA is commonly added, typically at about 0.1%, to the matrix or sample solution in MALDI-TOF mass spectrometry for protein analysis, and is used as a counterion in HPLC to improve peptide separation.
What is it used for?
Besides protein and peptide analysis, trifluoroacetic acid is a general laboratory reagent. It is used as a strong non-oxidizing acid, a solvent and a catalyst in organic synthesis, including the production of other organic chemicals.
What is the chemical formula and molecular weight of trifluoroacetic acid?
The formula is **CF₃COOH**, and the molecular weight is **114.02 g/mol**.
What safety classification does trifluoroacetic acid hold?
TFA is labeled with the **Signal Word: Danger** due to its corrosive and hazardous properties.
How should trifluoroacetic acid be stored?
Store TFA in a tightly sealed container at **ambient temperature**, away from incompatible substances and moisture.
Does Molekula supply trifluoroacetic acid in bulk quantities?
Yes, we offer TFA in bulk packaging options—please contact us for specific volume requirements and pricing.
What documentation is provided with a trifluoroacetic acid order?
Each order includes a **Certificate of Analysis (CoA)**, Material Safety Data Sheet (MSDS), and a product specification sheet.
Ready to order or need a custom pack?
Tell us the product, grade, and quantity — Molekula usually responds within one working day with pricing and lead time.