Molekula
L-(+)-Amethopterin hydrate (Methotrexate)
Supplying 4,500+ customers in over 80 countries
ISO 9001:2015 & ISO 14001:2015 certified · Supplying laboratories and industry since 2000 · Listed pack sizes are a starting point — we manufacture, source and repack to the quantity you need
L-(+)-Amethopterin hydrate, also known as Methotrexate, is a folic acid antagonist used in chemotherapy and autoimmune disease treatment. It inhibits dihydrofolate reductase, disrupting DNA synthesis. Available with CAS number 59-05-2, molecular formula C20H22N8O5, and molecular weight 454.44 g/mol. Stored at -15 to -20 °C. Signal word: Danger. Molekula supplies L-(+)-Amethopterin hydrate from research to bulk quantities with full documentation and ISO 9001:2015 traceability.
Example image for illustration only. Other packaging and pack sizes are available.
Pricing & pack sizes
These pack sizes aren't a limit. Molekula manufactures, sources and repacks to order — if you need 500 kg and only see 1 kg listed, . We quote from grams to multi-tonne.
Need a different size? Add the nearest pack and change the size in your basket — we price it at the same rate per unit.
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5 mg — £28.00 per pack ex VAT · £33.60 inc. VAT
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100 mg — £93.30 per pack ex VAT · £111.96 inc. VAT
Need a different quantity or pack?
Tell us how much you need and when — drums, IBCs, sacks or a one-off bulk lot. We'll manufacture or source it and come back with a price.
Prices exclude VAT/sales tax and shipping.
Specifications
| Property | Value |
|---|---|
| Appearance | Yellow or orange crystalline, hygroscopic powder |
| Water | ≤ 13.0% |
| Impurity B | ≤ 0.3% |
| Heavy metals | ≤ 20ppm |
| Acetone | ≤ 1000 ppm |
| Impurity C | ≤ 0.5% |
| Solubility | Practically insolubile in water, in ethanol (96%) and in methylene chloride. It dissolves in dilute mineral acids and in dilute solutions od alkali hydroxides and carbonates |
| Assay | 98 - 102% |
| Sulphated Ash | ≤ 0.1% |
| Ethanol | ≤ 2000 ppm |
| Bacterial endotoxins | ≤ 0.1 EU/mg |
| Enantiomeric Purity | ≤ 3.0% |
| Identification (IR) | The IR spectrum of sample exhibits maxima only at the same wavelength as that a similar preparation of methotrexate CRS |
| Impurity E | ≤ 0.3% |
| Impurity H | ≤ 0.2% |
| Impurity I | ≤ 0.2% |
| Ethyl Ether | ≤ 500 ppm |
Storage & handling
| Property | Value |
|---|---|
| Storage Temperature | -15 to -20 °C |
| Transport Class | 6.1 |
| Packing Group | III |
| Acidity | Base |
Literature values
Published physical properties of the substance, not batch specifications.
| Property | Value |
|---|---|
| Appearance | Orange-brown, crystalline powder |
| Melting Point | 195 °C |
| Vapour Pressure | 2.1 × 10⁻¹⁹ mmHg at 25 °C (Estimated) |
| pKa | pKa = 4.7 |
| log P (octanol/water) | -1.85 |
Source: PubChem CID 126941 (HSDB, DrugBank)
Identification
| Property | Value |
|---|---|
| SKU | 30186373 |
| CAS Number | 59-05-2 |
| IUPAC Name | (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid |
| EC Number | 200-413-8 |
| Molecular Formula | C20H22N8O5 |
| Molecular Weight | 454.44 |
| Exact Mass | 454.1713 |
| SMILES | CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O |
| InChIKey | FBOZXECLQNJBKD-ZDUSSCGKSA-N |
| InChI | InChI=1S/C20H22N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)/t13-/m0/s1 |
| PubChem CID | 126941 |
| UN Number | UN1544 |
| REACH Code | Y110 |
| TSCA Listed | Yes |
| HTS Code | 29335995 |
| Tariff Code | 2933599590 |
Safety & GHS
-
Toxic
GHS06
-
Health Hazard
GHS07
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Serious Health Hazard
GHS08
Hazard statements
- H301 Toxic if swallowed
- H315 Causes skin irritation
- H319 Causes serious eye irritation
- H335 May cause respiratory irritation
- H340 May cause genetic defects
- H360 May damage fertility or the unborn child
Precautionary statements
- P201 Obtain special instructions before use
- P280 Wear protective gloves/protective clothing/eye protection/face protection
- P301+310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician
- P302+352 IF ON SKIN: Wash with soap and water
- P304+340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing
- P305+351+338 IF IN EYES: Rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing
Documents
Safety Data Sheets (SDS)
Available in English, French, German, Italian, Spanish.
Certificate of Analysis (CoA) by batch
Enter a lot or batch number to retrieve the CoA for that specific batch. We can generate one from spec data if no PDF is on file.
Synonyms
- Amethopterin
- Antifolan
- Hdmtx
- Ledertrexate
- Metatrexan
- methotrexate
- Methotrexatum
- Methylaminopterinum
- Metotrexato
- Rheumatrex
Frequently asked questions
What is L-(+)-Amethopterin hydrate used for?
It is primarily used as an antifolate drug in chemotherapy and autoimmune disease treatment, inhibiting dihydrofolate reductase.
What is the chemical formula and molecular weight of L-(+)-Amethopterin hydrate?
The formula is C20H22N8O5 with a molecular weight of 454.44 g/mol.
How should L-(+)-Amethopterin hydrate be stored?
It must be stored at -15 to -20 °C to maintain stability and prevent degradation.
What grade of L-(+)-Amethopterin hydrate does Molekula supply?
We supply it as a research-grade chemical, suitable for laboratory use.
Can Molekula supply L-(+)-Amethopterin hydrate in bulk?
Yes, we can provide bulk quantities—please contact our sales team for pricing and availability.
What documentation comes with an order of L-(+)-Amethopterin hydrate?
Each order includes a Certificate of Analysis (CoA) and Safety Data Sheet (SDS) with the shipment.
Ready to order or need a custom pack?
Tell us the product, grade, and quantity — Molekula usually responds within one working day with pricing and lead time.