Molekula

L-(+)-Amethopterin hydrate (Methotrexate) - USP CRS

SKU 90038250 CAS 59-05-2 C20H22N8O5 MW 454.44 Available on enquiry

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L-(+)-Amethopterin hydrate, also known as Methotrexate USP CRS, is a potent chemotherapeutic agent and immunosuppressant used primarily in cancer treatment, autoimmune disease management, and ectopic pregnancy termination. It is a synthetic folate antagonist that inhibits dihydrofolate reductase, disrupting DNA synthesis in rapidly dividing cells. This chemical has a CAS number of 59-05-2, a molecular formula of C20H22N8O5, and a molecular weight of 454.44. It requires strict storage at -15 to -20°C and carries a **Danger** signal word due to its high toxicity. Molekula supplies L-(+)-Amethopterin hydrate from research to bulk quantities with full documentation and ISO 9001:2015 traceability.

This substance is available from Molekula on enquiry. Full specification, Safety Data Sheet and Certificate of Analysis documentation are provided with your quotation once our team confirms the grade and pack size you need.

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Overview

SKU: 90038250
CAS Number: 59-05-2
IUPAC Name: (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid
EC Number: 200-413-8
Molecular Formula: C20H22N8O5
Molecular Weight: 454.44
Exact Mass: 454.1713
SMILES: CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O
InChIKey: FBOZXECLQNJBKD-ZDUSSCGKSA-N
InChI: InChI=1S/C20H22N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)/t13-/m0/s1
PubChem CID: 126941

Synonyms

Amethopterin
Antifolan
Hdmtx
Ledertrexate
Metatrexan
methotrexate
Methotrexatum
Methylaminopterinum
Metotrexato
Rheumatrex

Literature values

Published physical properties of the substance, not batch specifications.

Appearance: Orange-brown, crystalline powder
Melting Point: 195 °C
Vapour Pressure: 2.1 × 10⁻¹⁹ mmHg at 25 °C (Estimated)
pKa: pKa = 4.7
log P (octanol/water): -1.85

Source: PubChem CID 126941 (HSDB, DrugBank)

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Frequently asked questions

What is L-(+)-Amethopterin hydrate (Methotrexate) USP CRS used for?

It is primarily used as a chemotherapy medication to treat cancer (e.g., leukemia, lymphoma) and as an immunosuppressiveant for autoimmune diseases like rheumatoid arthritis and psoriasis.

What is the chemical formula and molecular weight of Methotrexate USP CRS?

The chemical formula is **C₂₀H₂₂N₈O₅**, and the molecular weight is **454.44 g/mol**.

How should Methotrexate USP CRS be stored?

Store at **-15 to -20°C** to maintain stability and potency. Avoid exposure to light and moisture.

What grade of Methotrexate USP CRS does Molekula supply?

Molekula supplies **USP CRS (United States Pharmacopeia Chemical Reference Substance) grade**, meeting stringent purity and quality standards for pharmaceutical applications.

Can Molekula supply Methotrexate USP CRS in bulk quantities?

Yes, bulk quantities are available upon request, subject to regulatory compliance and customer requirements.

What documentation comes with an order of Methotrexate USP CRS?

Each order includes a **Certificate of Analysis (CoA)**, **Material Safety Data Sheet (MSDS)**, and **batch-specific documentation** to verify compliance with USP CRS standards.

Related products

Molekula has supplied fine chemicals and biochemicals since 2000 from ISO 9001:2015 and ISO 14001:2015 certified facilities. Every dispatched batch is logged with a batch number and matched to a Certificate of Analysis, and Safety Data Sheets are available in five languages.