L-(+)-Amethopterin hydrate (Methotrexate)
(30186373 | 59-05-2)

CAS: 59-05-2
Molecular Formula: C20H22N8O5
Molecular Weight: 454.44
Availablility: In Stock
Downloads: Product Specification | Safety Data Sheet [EN]
L-(+)-Amethopterin hydrate (Methotrexate) Chemical Structure

This product is subject to a hazardous surcharge. The exact amount will be confirmed by our sales team.

30186373-100mg 100mg £93.30
Bulk Order
30186373-100mg 100mg €130.70
Bulk Order
30186373-100mg 100mg $140.00
Bulk Order
Safety Data Sheet
Certificate of Analysis

Product Detail
Product Code 30186373
Product Name L-(+)-Amethopterin hydrate (Methotrexate)
Categories Bioactive Small Molecules Research Organics & Inorganics
CAS 59-05-2
Molecular Formula C20H22N8O5
Molecular Weight 454.44
Storage Details -15 to -20 °C
Harmonised Tariff Code 2933599590

Product Specification
Grade Ph. Eur. 8.3
Water <13%
Impurity B NMT 0.3%
Heavy metals NMT 20ppm
Bacterial endotoxin NMT 0.1 EU/mg
Acetone NMT 1000 ppm
Impurity C NMT 0.5%
Solubility Practically insolubile in water, in ethanol (96%) and in methylene chloride. It dissolves in dilute mineral acids and in dilute solutions od alkali hydroxides and carbonates
Assay 98 - 102%
Sulphated Ash NMT 0.1%
Ethanol NMT 2000 ppm
Appearance Yellow or orange crystalline, hygroscopic powder
Enantiomeric Purity NMT3.0%
Identification (IR) The IR spectrum of sample exhibits maxima only at the same wavelength as that a similar preparation of methotrexate CRS
Impurity E NMT 0.3%
Impurity H NMT 0.2%
Impurity I NMT 0.2%
Ethyl Ether NMT 500 ppm

Safety Information
Danger to Health
Skull and Cross Bones
Signal word danger
Hazard statements
  • H301: Toxic if swallowed

  • H315: Causes skin irritation

  • H319: Causes serious eye irritation

  • H360: May damage fertility or the unborn child
Precautionary statements
  • P201: Obtain special instructions before use

  • P280: Wear protective gloves/protective clothing/eye protection/face protection

  • P301+310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician

  • P305+351+338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do, continue rinsing

  • P308+313: IF exposed or concerned: Get medical advice/attention

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