Molekula
Trimethoprim USP CRS
Supplying 4,500+ customers in over 80 countries
ISO 9001:2015 & ISO 14001:2015 certified · Supplying laboratories and industry since 2000 · Listed pack sizes are a starting point — we manufacture, source and repack to the quantity you need
Trimethoprim USP CRS is a synthetic antibacterial compound, primarily used as a reference standard in pharmaceutical quality control and research to ensure the accuracy of trimethoprim-based drug formulations. It is also employed in microbiological assays to study its mechanism of action against bacterial infections. Trimethoprim itself is the active ingredient in veterinary antimicrobial medicines and is formulated with sulfamethoxazole in combination antibacterial products. This chemical has a CAS number of 738-70-5, with the molecular formula C14H18N4O3 and a molecular weight of 290.32. It must be stored between 2 to 8°C and carries a **Danger** signal word due to its hazardous properties. Molekula supplies Trimethoprim USP CRS from research to bulk quantities with full documentation and ISO 9001:2015 traceability.
Example image for illustration only. Other packaging and pack sizes are available.
Pricing & pack sizes
Pack sizes & pricing
Pricing on request — packs available from research to bulk quantities.
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Specifications
| Property | Value |
|---|---|
| Appearance | White to cream crystalline powder |
Storage & handling
| Property | Value |
|---|---|
| Storage Temperature | 2 to 8 °C |
| Transport Class | 9 |
| Packing Group | III |
| Acidity | Neutral |
Literature values
Published physical properties of the substance, not batch specifications.
| Property | Value |
|---|---|
| Appearance | White to cream, crystalline powder |
| Odour | Odorless |
| Melting Point | 199 - 203 °C |
| Water Solubility | 400 mg/L at 25 °C |
| Solubility (other solvents) | Very slightly soluble in water and slightly soluble in alcohol |
| pKa | pKa = 7.12 (at 20 °C) |
| log P (octanol/water) | 0.91 |
Source: PubChem CID 5578 (HSDB, Human Metabolome Database (HMDB), DrugBank)
Identification
| Property | Value |
|---|---|
| SKU | 90037622 |
| CAS Number | 738-70-5 |
| IUPAC Name | 5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine |
| EC Number | 212-006-2 |
| Molecular Formula | C14H18N4O3 |
| Molecular Weight | 290.32 |
| Exact Mass | 290.1379 |
| SMILES | COC1=CC(=CC(=C1OC)OC)CC2=CN=C(N=C2N)N |
| InChIKey | IEDVJHCEMCRBQM-UHFFFAOYSA-N |
| InChI | InChI=1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18) |
| PubChem CID | 5578 |
| UN Number | UN3077 |
| REACH Code | Y110 |
| HTS Code | 29335995 |
| Tariff Code | 2933599590 |
Safety & GHS
-
Health Hazard
GHS07
-
Serious Health Hazard
GHS08
-
Hazardous to the Environment
GHS09
Hazard statements
- H302 Harmful if swallowed
- H361d Suspected of damaging fertility. Suspected of damaging the unborn child.
- H373 May cause damage to organs through prolonged or repeated exposure
- H411 Toxic to aquatic life with long lasting effects
Precautionary statements
- P260 Do not breathe dust/fume/gas/mist/vapours/spray
- P273 Avoid release to the environment
- P280 Wear protective gloves/protective clothing/eye protection/face protection
- P301+312 IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell
- P308+313 IF exposed or concerned: Get medical advice/attention
Documents
Safety Data Sheets (SDS)
Available in English, French, German, Italian, Spanish.
Certificate of Analysis (CoA) by batch
Enter a lot or batch number to retrieve the CoA for that specific batch. We can generate one from spec data if no PDF is on file.
Synonyms
- 2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine
- Monoprim
- Monotrim
- Proloprim
- Syraprim
- trimethoprim
- Trimetoprim
- Trimopan
- Trimpex
- Wellcoprim
Frequently asked questions
What is Trimethoprim USP CRS primarily used for?
Trimethoprim USP CRS is used as a reference standard for analytical testing in pharmaceutical quality control, ensuring consistency in drug formulations containing trimethoprim.
What is the chemical formula and molecular weight of Trimethoprim USP CRS?
The chemical formula is **C14H18N4O3** and the molecular weight is **290.32 g/mol**.
How should Trimethoprim USP CRS be stored?
Store at **2 to 8°C** in a dry, well-ventilated area, protected from light and moisture.
What grade of Trimethoprim is this, and is it suitable for pharmaceutical applications?
This is **USP Certified Reference Standard (CRS) grade**, meeting strict purity and documentation requirements for pharmaceutical quality control.
Can Molekula supply Trimethoprim USP CRS in bulk quantities?
Yes, Molekula can supply Trimethoprim USP CRS in bulk, subject to minimum order quantities and regulatory compliance.
What documentation comes with an order of Trimethoprim USP CRS?
Each order includes a **Certificate of Analysis (CoA)**, **Material Safety Data Sheet (MSDS)**, and **USP CRS compliance documentation**.
Ready to order or need a custom pack?
Tell us the product, grade, and quantity — Molekula usually responds within one working day with pricing and lead time.