Molekula
Trifluoroacetic anhydride
Supplying 4,500+ customers in over 80 countries
ISO 9001:2015 & ISO 14001:2015 certified · Supplying laboratories and industry since 2000 · Listed pack sizes are a starting point — we manufacture, source and repack to the quantity you need
Trifluoroacetic anhydride is a highly reactive fluorinated acylating agent used in organic synthesis, particularly for trifluoroacetylation of amines and alcohols, dehydration of primary amides to nitriles, and modification of functional groups. It is a colorless to pale yellow liquid with a pungent odor. CAS: 407-25-0, molecular formula: (CF3CO)2O, molecular weight: 210.03 g/mol. Store at 2 to 8 °C. Hazardous: signal word Danger. Molekula supplies Trifluoroacetic anhydride from research to bulk quantities with full documentation and ISO 9001:2015 traceability.
Example image for illustration only. Other packaging and pack sizes are available.
Pricing & pack sizes
These pack sizes aren't a limit. Molekula manufactures, sources and repacks to order — if you need 500 kg and only see 1 kg listed, . We quote from grams to multi-tonne.
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100 g — £30.90 per pack ex VAT · £37.08 inc. VAT
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Tell us how much you need and when — drums, IBCs, sacks or a one-off bulk lot. We'll manufacture or source it and come back with a price.
Prices exclude VAT/sales tax and shipping.
Specifications
| Property | Value |
|---|---|
| Appearance | Colourless liquid |
| Chloride (Cl-) | ≤0.005% |
| Purity | ≥99.5% |
| Sulphates (SO4)(2-) | ≤0.05% |
| Fluoride (F-) | ≤0.005% |
Storage & handling
| Property | Value |
|---|---|
| Storage Temperature | 2 to 8 °C |
| Transport Class | 8 |
| Packing Group | I |
| Acidity | Acid |
Literature values
Published physical properties of the substance, not batch specifications.
| Property | Value |
|---|---|
| Boiling Point | 39.5 °C at 760 mmHg |
| Vapour Pressure | 41.2 mmHg |
Source: PubChem CID 9845 (PAC Chemical Database, Haz-Map)
Identification
| Property | Value |
|---|---|
| SKU | 19060783 |
| CAS Number | 407-25-0 |
| IUPAC Name | (2,2,2-trifluoroacetyl) 2,2,2-trifluoroacetate |
| EC Number | 206-982-9 |
| Molecular Formula | (CF3CO)2O |
| Molecular Weight | 210.03 |
| Exact Mass | 209.9752 |
| SMILES | C(=O)(C(F)(F)F)OC(=O)C(F)(F)F |
| InChIKey | QAEDZJGFFMLHHQ-UHFFFAOYSA-N |
| InChI | InChI=1S/C4F6O3/c5-3(6,7)1(11)13-2(12)4(8,9)10 |
| PubChem CID | 9845 |
| UN Number | UN3265 |
| REACH Code | Y110 |
| TSCA Listed | Yes |
| Tariff Code | 29159070 |
Safety & GHS
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Corrosive
GHS05
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Health Hazard
GHS07
Hazard statements
- EUH014 Reacts violently with water
- H290 May be corrosive to metals
- H302 + H312 + H332 Harmful if swallowed, in contact with skin or if inhaled
- H314 (sub cat. 1A) Causes severe skin burns and eye damage
- H361d Suspected of damaging fertility. Suspected of damaging the unborn child.
- H412 Harmful to aquatic life with long lasting effects
Precautionary statements
- P231+232 Handle under inert gas. Protect from moisture
- P260 Do not breathe dust/fume/gas/mist/vapours/spray
- P273 Avoid release to the environment
- P280 Wear protective gloves/protective clothing/eye protection/face protection
- P303+361 IF ON SKIN (or hair): Remove immediately all contaminated clothing. Rinse with water/shower
- P305+351+338 IF IN EYES: Rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing
- P310 Immediately call a POISON CENTER or doctor/physician
Documents
Safety Data Sheets (SDS)
Available in English, French, German, Italian, Spanish.
Certificate of Analysis (CoA) by batch
Enter a lot or batch number to retrieve the CoA for that specific batch. We can generate one from spec data if no PDF is on file.
Synonyms
- (2,2,2-trifluoroacetyl) 2,2,2-trifluoroacetate
- 2,2,2-trifluoroacetic anhydride
- Acetic acid, trifluoro-, anhydride
- Anhydrid kyseliny trifluoroctove
- Bis(trifluoroacetic) anhydride
- Hexafluoroacetic anhydride
- Perfluoroacetic anhydride
- TFAA
- Trifluoroacetic acid anhydride
- Trifluoroacetyl anhydride
Frequently asked questions
What is trifluoroacetic anhydride used for?
It is primarily used as a reagent in organic synthesis, particularly for acetylation and dehydration reactions in pharmaceutical manufacturing.
What is the chemical formula and molecular weight of trifluoroacetic anhydride?
The formula is (CF3CO)2O with a molecular weight of 210.03 g/mol.
How should trifluoroacetic anhydride be stored?
It must be stored at temperatures between 2 and 8 °C and protected from moisture and light.
What grade is available for trifluoroacetic anhydride?
Available in technical grade; custom purity options may be available upon request.
Can Molekula supply trifluoroacetic anhydride in bulk?
Yes, bulk quantities are available—please contact our sales team for pricing and availability.
What documentation comes with a purchase of trifluoroacetic anhydride?
Each order includes a Certificate of Analysis (CoA) and Safety Data Sheet (SDS); additional documentation can be provided upon request.
Ready to order or need a custom pack?
Tell us the product, grade, and quantity — Molekula usually responds within one working day with pricing and lead time.