Molekula
Phorbol-12-myristate-13-acetate
Supplying 4,500+ customers in over 80 countries
ISO 9001:2015 & ISO 14001:2015 certified · Supplying laboratories and industry since 2000 · Listed pack sizes are a starting point — we manufacture, source and repack to the quantity you need
Phorbol-12-myristate-13-acetate (PMA) is a potent phorbol ester and protein kinase C (PKC) activator widely used in cell biology research to induce differentiation, proliferation, and inflammatory responses in vitro. It serves as a key tool in studying signal transduction pathways, immune cell activation, and cancer research. This compound has a CAS number of 16561-29-8, with the molecular formula C36H56O8 and a molecular weight of 616.83 g/mol. It must be stored at -15 to -20°C and is classified with the signal word "Danger." Molekula supplies Phorbol-12-myristate-13-acetate from research to bulk quantities with full documentation and ISO 9001:2015 traceability.
Example image for illustration only. Other packaging and pack sizes are available.
Pricing & pack sizes
These pack sizes aren't a limit. Molekula manufactures, sources and repacks to order — if you need 500 kg and only see 1 kg listed, . We quote from grams to multi-tonne.
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1 mg — $127.20 per pack
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Specifications
| Property | Value |
|---|---|
| Appearance | White to off white solid |
| Assay | ≥98.0% |
Storage & handling
| Property | Value |
|---|---|
| Storage Temperature | -15 to -20 °C |
| Transport Class | 6.1 (8) |
| Packing Group | I |
| Acidity | Neutral |
Literature values
Published physical properties of the substance, not batch specifications.
| Property | Value |
|---|---|
| Appearance | Oil |
| Melting Point | 50-70 °C (melting pt-freezing pt) |
| Water Solubility | Insoluble in water |
Source: PubChem CID 27924 (HSDB)
Identification
| Property | Value |
|---|---|
| SKU | 90028661 |
| CAS Number | 16561-29-8 |
| IUPAC Name | [(1S,2S,6R,10S,11R,13S,14R,15R)-13-acetyloxy-1,6-dihydroxy-8-(hydroxymethyl)-4,12,12,15-tetramethyl-5-oxo-14-tetracyclo[8.5.0.02,6.011,13]pentadeca-3,8-dienyl] tetradecanoate |
| Molecular Formula | C36H56O8 |
| Molecular Weight | 616.83 |
| Exact Mass | 616.3975 |
| SMILES | CCCCCCCCCCCCCC(=O)O[C@@H]1[C@H]([C@]2([C@@H](C=C(C[C@]3([C@H]2C=C(C3=O)C)O)CO)[C@H]4[C@@]1(C4(C)C)OC(=O)C)O)C |
| InChIKey | PHEDXBVPIONUQT-RGYGYFBISA-N |
| InChI | InChI=1S/C36H56O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-29(39)43-32-24(3)35(42)27(30-33(5,6)36(30,32)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-20,24,27-28,30,32,37,41-42H,7-18,21-22H2,1-6H3/t24-,27+,28-,30-,32-,34-,35-,36-/m1/s1 |
| PubChem CID | 27924 |
| UN Number | UN2928 |
| REACH Code | Y110 |
| HTS Code | 29153990 |
| Tariff Code | 2915390090 |
Safety & GHS
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Toxic
GHS06
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Health Hazard
GHS07
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Serious Health Hazard
GHS08
Hazard statements
- H300 +H310 + H330 Fatal if swallowed, in contact with skin or if inhaled
- H314 (sub cat. 1B) Causes severe skin burns and eye damage
- H317 May cause an allergic skin reaction
- H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled
- H351 Suspected of causing cancer
Precautionary statements
- P260 Do not breathe dust/fume/gas/mist/vapours/spray
- P280 Wear protective gloves/protective clothing/eye protection/face protection
- P301+310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician
- P302+352 IF ON SKIN: Wash with soap and water
- P304+340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing
- P305+351+338 IF IN EYES: Rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing
Documents
Safety Data Sheets (SDS)
Available in English, French, German, Italian, Portuguese, Russian, Spanish.
Certificate of Analysis (CoA) by batch
Enter a lot or batch number to retrieve the CoA for that specific batch. We can generate one from spec data if no PDF is on file.
Synonyms
- 12-O-Tetradecanoylphorbol-13-acetate
- 13-O-Acetylphorbol 12-myristate
- Factor A1
- Phorbol 12-tetradecanoate 13-acetate
- phorbol 13-acetate 12-myristate
- Phorbol myristate acetate
- Pma (phorbol ester)
- PMA (tumor promoter)
- Tetradecanoylphorbol acetate
- TPA (phorbol derivative)
Frequently asked questions
What is Phorbol-12-myristate-13-acetate (PMA) commonly used for in research?
PMA is widely used as a potent activator of protein kinase C (PKC) in cell signaling studies, particularly in research on inflammation, tumor promotion, and immune response.
What is the chemical formula and molecular weight of PMA?
The chemical formula is **C₃₆H₅₆O₈**, and the molecular weight is **616.83 g/mol**.
How should PMA be stored to maintain stability?
PMA must be stored at **-15 to -20°C** to preserve its activity and prevent degradation.
What grade or purity is available for PMA from Molekula?
Molekula supplies PMA in **research-grade purity**, typically ≥98% as determined by HPLC or similar analytical methods.
Can Molekula supply PMA in bulk quantities for large-scale research projects?
Yes, Molekula can provide PMA in bulk, with quantities tailored to meet specific research or production needs—please contact us for pricing and availability.
What documentation is provided with a PMA order?
Each order includes a **Certificate of Analysis (CoA)**, **Material Safety Data Sheet (MSDS)**, and **batch-specific documentation** for traceability.
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