Molekula
Naloxone - USP CRS
Supplying 4,500+ customers in over 80 countries
ISO 9001:2015 & ISO 14001:2015 certified · Supplying laboratories and industry since 2000 · Listed pack sizes are a starting point — we manufacture, source and repack to the quantity you need
Naloxone USP CRS is a synthetic opioid antagonist used primarily in emergency medicine to rapidly reverse opioid overdose by binding to opioid receptors without activating them. It is also employed in research settings to study opioid receptor mechanisms. This chemical has a CAS number of 465-65-6, a molecular formula of C19H21NO4, and a molecular weight of 327.37. It must be stored between 2 to 8°C and carries a signal word of "Danger." Molekula supplies Naloxone USP CRS from research to bulk quantities with full documentation and ISO 9001:2015 traceability.
Example image for illustration only. Other packaging and pack sizes are available.
Pricing & pack sizes
Pack sizes & pricing
Pricing on request — packs available from research to bulk quantities.
Need a different quantity or pack?
Tell us how much you need and when — drums, IBCs, sacks or a one-off bulk lot. We'll manufacture or source it and come back with a price.
Prices exclude VAT/sales tax and shipping.
Specifications
| Property | Value |
|---|---|
| Appearance | White to off-white powder |
Storage & handling
| Property | Value |
|---|---|
| Storage Temperature | 2 to 8 °C |
| Acidity | Neutral |
Literature values
Published physical properties of the substance, not batch specifications.
| Property | Value |
|---|---|
| Melting Point | 177 °C |
| Solubility (other solvents) | Soluble in chloroform; practically insoluble in petroleum ether |
| pKa | pKa = 7.94 |
| log P (octanol/water) | 2.09 |
Source: PubChem CID 5284596 (DrugBank, HSDB, ChEMBL)
Identification
| Property | Value |
|---|---|
| SKU | 90034180 |
| CAS Number | 465-65-6 |
| IUPAC Name | (4R,4aS,7aR,12bS)-4a,9-dihydroxy-3-prop-2-enyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one |
| EC Number | 207-365-7 |
| Molecular Formula | C19H21NO4 |
| Molecular Weight | 327.37 |
| Exact Mass | 327.1471 |
| SMILES | C=CCN1CC[C@]23[C@@H]4C(=O)CC[C@]2([C@H]1CC5=C3C(=C(C=C5)O)O4)O |
| InChIKey | UZHSEJADLWPNLE-GRGSLBFTSA-N |
| InChI | InChI=1S/C19H21NO4/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11/h2-4,14,17,21,23H,1,5-10H2/t14-,17+,18+,19-/m1/s1 |
| PubChem CID | 5284596 |
| REACH Code | Y110 |
| HTS Code | 29391920 |
| Tariff Code | 2939190000 |
Safety & GHS
-
Corrosive
GHS05
-
Health Hazard
GHS07
Hazard statements
- H302 Harmful if swallowed
- H318 Causes serious eye damage
- H412 Harmful to aquatic life with long lasting effects
Precautionary statements
- P273 Avoid release to the environment
- P280 Wear protective gloves/protective clothing/eye protection/face protection
- P301+312 IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell
- P305+351+338 IF IN EYES: Rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing
- P337+313 If eye irritation persists get medical advice/attention
Documents
Certificate of Analysis (CoA) by batch
Enter a lot or batch number to retrieve the CoA for that specific batch. We can generate one from spec data if no PDF is on file.
Synonyms
- 1-N-Allyl-14-hydroxynordihydromorphinone
- DBL Naloxone
- EN 1530 base
- l-Naloxone
- n-Allylnoroxymorphone
- Nalossone
- Naloxona
- naloxone
- Naloxone Nasal Spray
- Naloxonum
Frequently asked questions
What is Naloxone USP CRS used for?
Naloxone USP CRS is primarily used as an opioid antagonist to rapidly reverse opioid overdose, including respiratory depression.
What is the chemical formula and molecular weight of Naloxone USP CRS?
The chemical formula is **C19H21NO4**, and the molecular weight is **327.37 g/mol**.
How should Naloxone USP CRS be stored?
Store at **2 to 8°C** (refrigerated) to maintain stability and potency.
What grade of Naloxone is this, and what does USP CRS mean?
USP CRS (United States Pharmacopeia Chemical Reference Substance) indicates a high-purity, analytically validated grade suitable for pharmaceutical and clinical applications.
Can Molekula supply Naloxone USP CRS in bulk quantities?
Yes, Molekula can provide bulk quantities of Naloxone USP CRS upon request, subject to availability and regulatory compliance.
What documentation comes with an order of Naloxone USP CRS?
Each order includes a **Certificate of Analysis (CoA)**, **Material Safety Data Sheet (MSDS)**, and **batch-specific documentation** for traceability.
Ready to order or need a custom pack?
Tell us the product, grade, and quantity — Molekula usually responds within one working day with pricing and lead time.