Molekula
N-Methyl-N-(trimethylsilyl)trifluoroacetamide
Supplying 4,500+ customers in over 80 countries
ISO 9001:2015 & ISO 14001:2015 certified · Supplying laboratories and industry since 1999 · Listed pack sizes are a starting point — we manufacture, source and repack to the quantity you need
N-Methyl-N-(trimethylsilyl)trifluoroacetamide is a silylating agent used in organic synthesis, particularly for derivatizing alcohols, amines, and carboxylic acids in analytical chemistry and pharmaceutical research. It is a colorless to pale yellow liquid with a molecular formula of CF3CON(CH3)Si(CH3)3, a molecular weight of 199.25 g/mol, and a CAS number of 24589-78-4. Store at 2 to 8 °C. Signal word: Warning.
Molekula supplies N-Methyl-N-(trimethylsilyl)trifluoroacetamide at ≥96.0% purity (GC) in 10 g packs, from £132.00 inc. VAT. It is in stock for same-day dispatch. Every batch ships with a certificate of analysis, and safety data sheets are available in 5 languages. Larger quantities, up to multi-tonne, are quoted on request.
Example image for illustration only. Other packaging and pack sizes are available.
Pricing & pack sizes
In stock — same-day dispatch
These pack sizes aren't a limit. Molekula manufactures, sources and repacks to order — if you need 500 kg and only see 1 kg listed, . We quote from grams to multi-tonne.
Need a different size? Add the nearest pack and change the size in your basket — we price it at the same rate per unit.
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10 g — £110.00 per pack ex VAT · £132.00 inc. VAT
Need a different quantity or pack?
Tell us how much you need and when — drums, IBCs, sacks or a one-off bulk lot. We'll manufacture or source it and come back with a price.
Prices exclude VAT/sales tax and shipping.
Specifications
| Property | Value |
|---|---|
| Appearance | Clear colourless to light yellow liquid |
| Assay (GC) | ≥96.0% |
| Identification (IR) | Conforms to structure |
Storage & handling
| Property | Value |
|---|---|
| Storage Temperature | 2 to 8 °C |
| Flash Point | 25 °C |
| Transport Class | 3 |
| Packing Group | III |
| Acidity | Neutral |
Identification
| Property | Value |
|---|---|
| SKU | 90027449 |
| CAS Number | 24589-78-4 |
| IUPAC Name | 2,2,2-trifluoro-N-methyl-N-trimethylsilylacetamide |
| EC Number | 246-331-6 |
| Molecular Formula | CF3CON(CH3)Si(CH3)3 |
| Molecular Weight | 199.25 |
| Exact Mass | 199.064 |
| SMILES | CN(C(=O)C(F)(F)F)[Si](C)(C)C |
| InChIKey | MSPCIZMDDUQPGJ-UHFFFAOYSA-N |
| InChI | InChI=1S/C6H12F3NOSi/c1-10(12(2,3)4)5(11)6(7,8)9/h1-4H3 |
| PubChem CID | 32510 |
| UN Number | UN1993 |
| REACH Code | Y110 |
| TSCA Listed | Yes |
| HTS Code | 29319090 |
| Tariff Code | 2931900090 |
Safety & GHS
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Flammable
GHS02
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Health Hazard
GHS07
Hazard statements
- H226 Flammable liquid and vapour
- H315 Causes skin irritation
- H319 Causes serious eye irritation
- H335 May cause respiratory irritation
Precautionary statements
- P210 Keep away from heat/sparks/open flames/hot surfaces - No smoking
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray
- P280 Wear protective gloves/protective clothing/eye protection/face protection
- P302+352 IF ON SKIN: Wash with soap and water
- P305+351+338 IF IN EYES: Rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing
Documents
Safety Data Sheets (SDS)
Available in English, French, German, Italian, Spanish.
Certificate of Analysis (CoA) by batch
Enter a lot or batch number to retrieve the CoA for that specific batch. We can generate one from spec data if no PDF is on file.
Quality certificates
Molekula Group is certified to ISO 9001:2015 (quality) and ISO 14001:2015 (environmental management), audited by a UKAS-accredited body. Both certificates are valid to 17 May 2028.
Synonyms
- 2,2,2-Trifluoro-N-methyl-N-(trimethylsilyl)acetamide
- ACETAMIDE, 2,2,2-TRIFLUORO-N-METHYL-N-(TRIMETHYLSILYL)-
- Acetamide,2,2-trifluoro-N-methyl-N-(trimethylsilyl)-
- C6H12F3NOSi
- MSTFA
- MSTFA; N-Methyl-N-(trimethylsilyl)trifluoroacetamide
- N-Methyl-N-trimethylsilyl-2,2,2-trifluoroacetamide
- N-methyl(trimethylsilyl)trifluoroacetamide
- N-Methyltrifluoroacetamide, TMS derivative
- N-Trimethylsilyl-N-methyl trifluoroacetamide
Frequently asked questions
What is N-Methyl-N-(trimethylsilyl)trifluoroacetamide used for?
It is primarily used as a silylating agent in organic synthesis, particularly for the derivatization of alcohols, amines, and carboxylic acids in analytical chemistry and pharmaceutical research.
What is the chemical formula and molecular weight?
The formula is CF3CON(CH3)Si(CH3)3 with a molecular weight of 199.25 g/mol.
How should this compound be stored?
Store at 2 to 8 °C in a cool, dry place, protected from light and moisture.
What grade is available?
It is supplied with an assay (GC) of ≥96.0%, as a clear colourless to light yellow liquid with identity confirmed by IR.
Can Molekula supply this in bulk?
Yes, Molekula can supply N-Methyl-N-(trimethylsilyl)trifluoroacetamide in bulk quantities—please contact our sales team for pricing and availability.
What documentation comes with the order?
Each order includes a Certificate of Analysis (CoA) and Safety Data Sheet (SDS); additional documentation can be provided upon request.
Where can I buy N-Methyl-N-(trimethylsilyl)trifluoroacetamide?
Directly from Molekula, which lists N-Methyl-N-(trimethylsilyl)trifluoroacetamide in 10 g packs from £132.00 inc. VAT, with a certificate of analysis for every batch. Larger quantities are quoted on request. Molekula's offices: United Kingdom, France, Spain, Germany, Italy, United States and China.
Is N-Methyl-N-(trimethylsilyl)trifluoroacetamide dangerous goods for shipping?
Yes. N-Methyl-N-(trimethylsilyl)trifluoroacetamide ships as dangerous goods: UN1993, class 3, packing group III.
Ready to order or need a custom pack?
Tell us the product, grade, and quantity — Molekula usually responds within one working day with pricing and lead time.