Molekula
N-(2-Chlorobenzyloxycarbonyloxy)succinimide (Z-(2-Cl)-)Su)
Supplying 4,500+ customers in over 80 countries
ISO 9001:2015 & ISO 14001:2015 certified · Supplying laboratories and industry since 2000 · Listed pack sizes are a starting point — we manufacture, source and repack to the quantity you need
N-(2-Chlorobenzyloxycarbonyloxy)succinimide (Z-(2-Cl)-Su) is an N-hydroxysuccinimide carbonate, an acylating reagent commonly used in peptide synthesis to introduce the 2-chlorobenzyloxycarbonyl (2-Cl-Z) protecting group onto amines during solid-phase peptide assembly. It ensures controlled coupling efficiency and minimizes side reactions, improving yield and purity in pharmaceutical and biochemical research. This chemical has a CAS number of 65853-65-8, molecular formula C12H10ClNO5, and a molecular weight of 283.66 g/mol. Store it between 2 to 8°C, and handle with caution—it carries a signal word of Warning due to potential irritation. Molekula supplies N-(2-Chlorobenzyloxycarbonyloxy)succinimide from research to bulk quantities with full documentation and ISO 9001:2015 traceability.
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Pricing & pack sizes
Pack sizes & pricing
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Specifications
| Property | Value |
|---|---|
| Appearance | Off-white crystalline powder |
| Melting Point | 102 - 105°C |
| Purity (HPLC) | ≥ 98.0% |
| Loss on Drying | ≤ 0.5% |
| Identification (IR) | Conforms to Reference |
Storage & handling
| Property | Value |
|---|---|
| Storage Temperature | 2 to 8 °C |
| Acidity | Neutral |
Identification
| Property | Value |
|---|---|
| SKU | 40931091 |
| CAS Number | 65853-65-8 |
| IUPAC Name | (2-chlorophenyl)methyl (2,5-dioxopyrrolidin-1-yl) carbonate |
| Molecular Formula | C12H10ClNO5 |
| Molecular Weight | 283.66 |
| Exact Mass | 283.0248 |
| SMILES | C1CC(=O)N(C1=O)OC(=O)OCC2=CC=CC=C2Cl |
| InChIKey | LVZHXYXNMHCBKC-UHFFFAOYSA-N |
| InChI | InChI=1S/C12H10ClNO5/c13-9-4-2-1-3-8(9)7-18-12(17)19-14-10(15)5-6-11(14)16/h1-4H,5-7H2 |
| PubChem CID | 580665 |
| REACH Code | Y113 |
| HTS Code | 29280025 |
| Tariff Code | 2928009090 |
Safety & GHS
-
Health Hazard
GHS07
Hazard statements
- H317 May cause an allergic skin reaction
- H319 Causes serious eye irritation
Precautionary statements
- P280 Wear protective gloves/protective clothing/eye protection/face protection
- P302+352 IF ON SKIN: Wash with soap and water
- P305+351+338 IF IN EYES: Rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing
- P332+313 IF skin irritation occurs: Get medical advice/attention
- P337+313 If eye irritation persists get medical advice/attention
Documents
Certificate of Analysis (CoA) by batch
Enter a lot or batch number to retrieve the CoA for that specific batch. We can generate one from spec data if no PDF is on file.
Synonyms
- (2-chlorophenyl)methyl (2,5-dioxopyrrolidin-1-yl) carbonate
- 2-Chlorobenzyl (2,5-dioxopyrrolidin-1-yl) carbonate
- 2-Chlorobenzyl succinimidyl carbonate
- 2,5-Pyrrolidinedione, 1-[[[(2-chlorophenyl)methoxy]carbonyl]oxy]-
- LVZHXYXNMHCBKC-UHFFFAOYSA-N
- N-(2-Chlorobenzyloxycarbonyl)succinimide
- N-(2-Chlorobenzyloxycarbonyloxy)succinimide
- N-(2-Chlorocarbobenzoxyoxy)succinimide
- N-(O-Chlorocarbobenzoxyoxy)succinimide
- Z(2-Cl)-OSu
Frequently asked questions
What is N-(2-Chlorobenzyloxycarbonyloxy)succinimide (Z-(2-Cl)-Su) used for?
This compound is primarily used in peptide synthesis as an acylating reagent for Boc-based solid-phase synthesis, particularly for introducing the 2-chlorobenzyloxycarbonyl (2-Cl-Z) carbamate protecting group, typically on the lysine side chain, as in the preparation of Boc-Lys(2-Cl-Z)-OH. The 2-Cl-Z group is stable to TFA and is removed by HF or other strong acids.
What is the molecular formula and molecular weight of Z-(2-Cl)-Su?
The molecular formula is C₁₂H₁₀ClNO₅, and the molecular weight is 283.66 g/mol.
How should Z-(2-Cl)-Su be stored?
Store at 2–8°C in a cool, dry place, protected from light and moisture. Follow standard chemical handling practices for sensitive reagents.
What grade or purity is available for this product?
Molekula supplies this reagent in analytical/HPLC-grade purity (≥98%) for research and synthesis applications.
Can Molekula supply Z-(2-Cl)-Su in bulk quantities?
Yes, bulk quantities are available upon request—contact our sales team for pricing and lead times tailored to your needs.
What documentation comes with an order of Z-(2-Cl)-Su?
Each order includes a Certificate of Analysis (CoA), Material Safety Data Sheet (MSDS), and batch-specific documentation for traceability.
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