Molekula
Methotrexate disodium salt
Supplying 4,500+ customers in over 80 countries
ISO 9001:2015 & ISO 14001:2015 certified · Supplying laboratories and industry since 2000 · Listed pack sizes are a starting point — we manufacture, source and repack to the quantity you need
Methotrexate disodium salt is a potent antimetabolite chemotherapy agent primarily used in the treatment of certain cancers, autoimmune diseases like psoriasis and rheumatoid arthritis, and ectopic pregnancies. It inhibits dihydrofolate reductase, disrupting DNA synthesis in rapidly dividing cells. This chemical has a CAS number of 7413-34-5, a molecular formula of C20H20N8Na2O5, and a molecular weight of 498.40 g/mol. It must be stored at -15 to -20°C and is classified with the signal word "Danger" due to its high toxicity. Molekula supplies Methotrexate disodium salt from research to bulk quantities with full documentation and ISO 9001:2015 traceability.
Example image for illustration only. Other packaging and pack sizes are available.
Pricing & pack sizes
Pack sizes & pricing
Pricing on request — packs available from research to bulk quantities.
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Specifications
| Property | Value |
|---|---|
| Appearance | Orange-brown or yellow crystalline powder- free from black/brown particualte |
| Water | ≤20.0% |
| Heavy metals | ≤20ppm |
| Single Impurity | ≤0.5% |
| Solubility | Practically soluble in water in chloroform in alcohol and in ether, freely soluble in dilute solutions of alkali hydroxides and carbonates, slightly soluble in 6N hydrochloric acid |
| Assay | ≥98.5% |
| Total Impurities | ≤2.0% |
| Sodium Identification | Positive |
Storage & handling
| Property | Value |
|---|---|
| Storage Temperature | -15 to -20 °C |
| Transport Class | 6.1 |
| Packing Group | III |
| Acidity | Neutral |
Identification
| Property | Value |
|---|---|
| SKU | 90037239 |
| CAS Number | 7413-34-5 |
| IUPAC Name | disodium;(2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioate |
| EC Number | 231-022-0 |
| Molecular Formula | C20H20N8Na2O5 |
| Molecular Weight | 498.40 |
| Exact Mass | 498.1352 |
| SMILES | CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-].[Na+].[Na+] |
| InChIKey | DASQOOZCTWOQPA-GXKRWWSZSA-L |
| InChI | InChI=1S/C20H22N8O5.2Na/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30;;/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27);;/q;2*+1/p-2/t13-;;/m0../s1 |
| PubChem CID | 11329481 |
| UN Number | UN2811 |
| REACH Code | Y110 |
| TSCA Listed | Yes |
| HTS Code | 29335980 |
| Tariff Code | 2933599590 |
Safety & GHS
-
Toxic
GHS06
-
Serious Health Hazard
GHS08
Hazard statements
- H301 Toxic if swallowed
- H315 Causes skin irritation
- H319 Causes serious eye irritation
- H335 May cause respiratory irritation
- H340 May cause genetic defects
- H360 May damage fertility or the unborn child
Precautionary statements
- P260 Do not breathe dust/fume/gas/mist/vapours/spray
- P263 Avoid contact during pregnancy/while nursing
- P301+310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician
- P302+352 IF ON SKIN: Wash with soap and water
- P305+351+338 IF IN EYES: Rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing
- P308+313 IF exposed or concerned: Get medical advice/attention
Documents
Safety Data Sheets (SDS)
Available in English, French, German, Italian, Spanish.
Certificate of Analysis (CoA) by batch
Enter a lot or batch number to retrieve the CoA for that specific batch. We can generate one from spec data if no PDF is on file.
Synonyms
- Abitrexate
- Disodium methotrexate
- Folex Pfs
- Methotrexate Lpf
- METHOTREXATE SODIUM
- Methotrexate sodium salt
- Mexate-Aq
- Mexate-Aq Preserved
- Sodium methotrexate
- Trexall
Frequently asked questions
What is Methotrexate disodium salt commonly used for?
Methotrexate disodium salt is primarily used as a chemotherapy medication to treat cancer (e.g., leukemia, lymphoma) and autoimmune diseases like rheumatoid arthritis and psoriasis.
What is the chemical formula and molecular weight of Methotrexate disodium salt?
The chemical formula is **C₂₀H₂₀N₈Na₂O₅**, and the molecular weight is **498.40 g/mol**.
How should Methotrexate disodium salt be stored?
Store at **-15 to -20°C** to maintain stability and potency.
What grades or purities of Methotrexate disodium salt does Molekula supply?
Molekula supplies **pharmaceutical-grade** Methotrexate disodium salt, meeting strict regulatory standards for research and clinical applications.
Can Molekula supply Methotrexate disodium salt in bulk quantities?
Yes, we can provide bulk quantities of Methotrexate disodium salt, subject to availability and compliance with applicable regulations.
What documentation comes with an order of Methotrexate disodium salt?
Each order includes a **Certificate of Analysis (CoA)**, **Material Safety Data Sheet (MSDS)**, and **batch-specific documentation** to ensure traceability and compliance.
Ready to order or need a custom pack?
Tell us the product, grade, and quantity — Molekula usually responds within one working day with pricing and lead time.