Molekula
Hyroxypropyl methylcellulose acetate succinate
Supplying 4,500+ customers in over 80 countries
ISO 9001:2015 & ISO 14001:2015 certified · Supplying laboratories and industry since 1999 · Listed pack sizes are a starting point — we manufacture, source and repack to the quantity you need
Hydroxypropyl methylcellulose acetate succinate (HPMCAS) is a semi-synthetic polymer used primarily as a pH-dependent excipient in pharmaceuticals, food, and cosmetics for controlled drug release, film coating, and stabilisation. This versatile derivative of cellulose offers tailored solubility and viscosity profiles. CAS 71138-97-1, molecular formula C10H22O9 (repeat unit), molecular weight 286.28 g/mol. Non-hazardous under standard conditions; store at ambient temperatures. Molekula supplies HPMCAS from research to bulk quantities with full documentation and ISO 9001:2015 traceability.
Example image for illustration only. Other packaging and pack sizes are available.
Pricing & pack sizes
Pack sizes & pricing
Pricing on request — packs available from research to bulk quantities.
Need a different quantity or pack?
Tell us how much you need and when — drums, IBCs, sacks or a one-off bulk lot. We'll manufacture or source it and come back with a price.
Prices exclude VAT/sales tax and shipping.
Specifications
| Property | Value |
|---|---|
| Appearance | White to light yellow powder |
| Identification | Conforms to reference |
Storage & handling
| Property | Value |
|---|---|
| Storage Temperature | Ambient |
| Acidity | Acid |
Identification
| Property | Value |
|---|---|
| SKU | 90037932 |
| CAS Number | 71138-97-1 |
| IUPAC Name | acetic acid;butanedioic acid;methanol;propane-1,2-diol |
| Molecular Formula | C10H22O9 |
| Molecular Weight | 286.28 |
| Exact Mass | 286.1264 |
| SMILES | CC(CO)O.CC(=O)O.CO.C(CC(=O)O)C(=O)O |
| InChIKey | ZUAAPNNKRHMPKG-UHFFFAOYSA-N |
| InChI | InChI=1S/C4H6O4.C3H8O2.C2H4O2.CH4O/c5-3(6)1-2-4(7)8;1-3(5)2-4;1-2(3)4;1-2/h1-2H2,(H,5,6)(H,7,8);3-5H,2H2,1H3;1H3,(H,3,4);2H,1H3 |
| PubChem CID | 121950 |
| REACH Code | Y113 |
| HTS Code | 3912390000 |
| Tariff Code | 3912398590 |
Safety & GHS
Precautionary statements
- P264 Wash thoroughly after handling
- P280 Wear protective gloves/protective clothing/eye protection/face protection
Documents
Safety Data Sheets (SDS)
Available in English, French, German, Italian, Portuguese, Spanish.
Certificate of Analysis (CoA) by batch
Enter a lot or batch number to retrieve the CoA for that specific batch. We can generate one from spec data if no PDF is on file.
Synonyms
- acetic acid;butanedioic acid;methanol;propane-1,2-diol
- acetic acid;methanol;propane-1,2-diol;succinic acid
- Cellulose, 2-hydroxypropyl methyl ether, acetate hydrogen butanedioate
- Cellulose,2-hydroxypropylmethylehter,acetatehydrogenbutanedioate
- Hpmcas
- hydroxypropylmethylcellulose acetate succinate
- Hypromellose acetate succinate
- Hypromellose ASLF; Affinisol HPMCAS 912G
Frequently asked questions
What is hydroxypropyl methylcellulose acetate succinate (HPMCAS) commonly used for?
HPMCAS is primarily used as a **pH-dependent polymer** in pharmaceutical formulations, particularly as a **enteric coating agent** for tablets and capsules to protect drug stability in the stomach and release in the intestine.
What is the molecular formula and molecular weight of HPMCAS?
The repeating unit formula is **C₁₀H₂₂O₉**, and the molecular weight of this segment is **286.28 g/mol** (note: the full polymer has a much higher MW due to polymerization).
How should HPMCAS be stored?
Store HPMCAS in a **cool, dry place at ambient temperature**, away from direct sunlight and moisture, in a tightly sealed container.
What grades or types of HPMCAS does Molekula supply?
Molekula supplies **pharmaceutical-grade HPMCAS** (e.g., HPMCAS-LF, HPMCAS-HF) with varying substitution levels for specific dissolution profiles—confirm exact grades and specifications upon inquiry.
Can Molekula supply HPMCAS in bulk quantities?
Yes, Molekula can provide HPMCAS in **bulk quantities** (e.g., 25kg drums, 1MT+), with flexible packaging options—contact us for pricing and lead times tailored to your order size.
What documentation is provided with an HPMCAS order?
Each order includes a **Certificate of Analysis (CoA)**, **Material Safety Data Sheet (MSDS)**, and **batch-specific documentation** (e.g., dissolution profile data for pharmaceutical grades) upon request.
Ready to order or need a custom pack?
Tell us the product, grade, and quantity — Molekula usually responds within one working day with pricing and lead time.