Molekula
Hexamethylphosphoramide
Supplying 4,500+ customers in over 80 countries
ISO 9001:2015 & ISO 14001:2015 certified · Supplying laboratories and industry since 2000 · Listed pack sizes are a starting point — we manufacture, source and repack to the quantity you need
Hexamethylphosphoramide (HMPA) is a polar aprotic solvent and strong ligand used in organic synthesis, particularly in nucleophilic substitution and metal-catalyzed reactions. Beyond the lab, it serves as a processing solvent for aromatic polyamide fibers and has been used as a polymerization catalyst and polymer stabilizer. It is a clear, colorless liquid with a molecular formula of OP[N(CH3)2]3, a molecular weight of 179.20 g/mol, and is stable at ambient storage conditions. It carries a Danger signal word because it causes severe skin burns and eye damage and may cause genetic defects and cancer. Molekula supplies Hexamethylphosphoramide from research to bulk quantities with full documentation and ISO 9001:2015 traceability.
Example image for illustration only. Other packaging and pack sizes are available.
Pricing & pack sizes
These pack sizes aren't a limit. Molekula manufactures, sources and repacks to order — if you need 500 kg and only see 1 kg listed, . We quote from grams to multi-tonne.
Need a different size? Add the nearest pack and change the size in your basket — we price it at the same rate per unit.
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100 g — £46.40 per pack ex VAT · £55.68 inc. VAT
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Tell us how much you need and when — drums, IBCs, sacks or a one-off bulk lot. We'll manufacture or source it and come back with a price.
Prices exclude VAT/sales tax and shipping.
Specifications
| Property | Value |
|---|---|
| Appearance | Colorless to light yellow transparent liquid |
| Water | <0.3% |
| Assay GC | >99% |
Storage & handling
| Property | Value |
|---|---|
| Storage Temperature | Ambient |
| Transport Class | 8 |
| Packing Group | III |
| Acidity | Base |
Literature values
Published physical properties of the substance, not batch specifications.
| Property | Value |
|---|---|
| Appearance | Colorless, mobile liquid |
| Odour | Aromatic odor |
| Melting Point | 7.2 °C |
| Boiling Point | 232 °C |
| Density | 1.03 (relative, water = 1) |
| Vapour Pressure | 4 Pa at 20 °C |
| Refractive Index | 1.4572 |
Source: PubChem CID 12679 (HSDB, ICSC)
Identification
| Property | Value |
|---|---|
| SKU | 16296919 |
| CAS Number | 680-31-9 |
| IUPAC Name | N-[bis(dimethylamino)phosphoryl]-N-methylmethanamine |
| EC Number | 211-653-8 |
| Molecular Formula | OP[N(CH3)2]3 |
| Molecular Weight | 179.20 |
| Exact Mass | 179.1187 |
| SMILES | CN(C)P(=O)(N(C)C)N(C)C |
| InChIKey | GNOIPBMMFNIUFM-UHFFFAOYSA-N |
| InChI | InChI=1S/C6H18N3OP/c1-7(2)11(10,8(3)4)9(5)6/h1-6H3 |
| PubChem CID | 12679 |
| UN Number | UN3267 |
| REACH Code | Y110 |
| HTS Code | 2929.90.5095 |
| Tariff Code | 2929909090 |
Safety & GHS
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Corrosive
GHS05
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Serious Health Hazard
GHS08
Hazard statements
- H303 May be harmful if swallowed
- H313 May be harmful in contact with skin
- H314 (sub cat. 1C) Causes severe skin burns and eye damage
- H340 May cause genetic defects
- H350 May cause cancer
Precautionary statements
- P260 Do not breathe dust/fume/gas/mist/vapours/spray
- P280 Wear protective gloves/protective clothing/eye protection/face protection
- P301+312 IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell
- P303+361 IF ON SKIN (or hair): Remove immediately all contaminated clothing. Rinse with water/shower
- P308+313 IF exposed or concerned: Get medical advice/attention
Documents
Safety Data Sheets (SDS)
Available in English, French, German, Italian, Spanish.
Certificate of Analysis (CoA) by batch
Enter a lot or batch number to retrieve the CoA for that specific batch. We can generate one from spec data if no PDF is on file.
Synonyms
- Eastman Inhibitor HPT
- Hempa
- Hexametapol
- Hexamethylphosphoric acid triamide
- Hexamethylphosphoric triamide
- Hexamethylphosphorotriamide
- HMPA
- HMPTA
- Phosphoric hexamethyltriamide
- Phosphoric triamide, hexamethyl-
Frequently asked questions
What is Hexamethylphosphoramide used for?
It is primarily used as a polar aprotic solvent in organic synthesis and as a reagent in the preparation of phosphorus-containing compounds.
What is the chemical formula and molecular weight of Hexamethylphosphoramide?
The formula is OP[N(CH3)2]3 with a molecular weight of 179.20 g/mol.
How should Hexamethylphosphoramide be stored?
It should be stored at ambient temperature, away from moisture and incompatible materials.
What grade is available for Hexamethylphosphoramide?
Available in technical grade; specific higher grades may be available upon request.
Can Molekula supply Hexamethylphosphoramide in bulk?
Yes, bulk quantities are available; please contact our sales team for pricing and availability.
What documentation comes with an order of Hexamethylphosphoramide?
Each order includes a Certificate of Analysis and Safety Data Sheet (SDS) with the shipment.
Ready to order or need a custom pack?
Tell us the product, grade, and quantity — Molekula usually responds within one working day with pricing and lead time.