Molekula
E-64
Supplying 4,500+ customers in over 80 countries
ISO 9001:2015 & ISO 14001:2015 certified · Supplying laboratories and industry since 2000 · Listed pack sizes are a starting point — we manufacture, source and repack to the quantity you need
E-64 is a potent, irreversible inhibitor of cysteine proteases, commonly used in biochemical research to study protease activity and function. It is available in high purity and is suitable for use in enzyme inhibition studies and cellular assays. Catalogue details: CAS 66701-25-5, molecular formula C15H27N5O5, molecular weight 357.41 g/mol, stored at 2 to 8 °C. Molekula supplies E-64 from research to bulk quantities with full documentation and ISO 9001:2015 traceability.
Example image for illustration only. Other packaging and pack sizes are available.
Pricing & pack sizes
These pack sizes aren't a limit. Molekula manufactures, sources and repacks to order — if you need 500 kg and only see 1 kg listed, . We quote from grams to multi-tonne.
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5 mg — £68.50 per pack ex VAT · £82.20 inc. VAT
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Specifications
| Property | Value |
|---|---|
| Appearance | White powder |
| Water | <5% |
| Purity (HPLC) | >98% |
| Single Impurity | <1% |
| Solubility | 20.0mg/in water clear soluble |
| TLC | >99% |
| HNMR | In accordance with the structure |
| Mass Spectrum | In accordance with the structure |
| Peptide content | 90 - 99% |
Storage & handling
| Property | Value |
|---|---|
| Storage Temperature | 2 to 8 °C |
| Acidity | Neutral |
Identification
| Property | Value |
|---|---|
| SKU | 12170327 |
| CAS Number | 66701-25-5 |
| IUPAC Name | (2S,3S)-3-[[(2S)-1-[4-(diaminomethylideneamino)butylamino]-4-methyl-1-oxopentan-2-yl]carbamoyl]oxirane-2-carboxylic acid |
| Molecular Formula | C15H27N5O5 |
| Molecular Weight | 357.41 |
| Exact Mass | 357.2012 |
| SMILES | CC(C)C[C@@H](C(=O)NCCCCN=C(N)N)NC(=O)[C@@H]1[C@H](O1)C(=O)O |
| InChIKey | LTLYEAJONXGNFG-DCAQKATOSA-N |
| InChI | InChI=1S/C15H27N5O5/c1-8(2)7-9(20-13(22)10-11(25-10)14(23)24)12(21)18-5-3-4-6-19-15(16)17/h8-11H,3-7H2,1-2H3,(H,18,21)(H,20,22)(H,23,24)(H4,16,17,19)/t9-,10-,11-/m0/s1 |
| PubChem CID | 123985 |
| REACH Code | Y110 |
| HTS Code | 2925.29.9000 |
| Tariff Code | 2925290090 |
Safety & GHS
Precautionary statements
- P280 Wear protective gloves/protective clothing/eye protection/face protection
Documents
Safety Data Sheets (SDS)
Available in English, French, German, Italian, Portuguese, Spanish.
Certificate of Analysis (CoA) by batch
Enter a lot or batch number to retrieve the CoA for that specific batch. We can generate one from spec data if no PDF is on file.
Synonyms
- (L-3-trans-Carboxyoxiran-2-carbonyl)-L-leucyl-admat
- E 64 (proteinase inhibitor)
- Proteinase inhibitor E 64
- Thiol protease inhibitor
- trans-epoxysuccinyl-l-leucylamido-(4-guanidino)butane
Frequently asked questions
What is E-64 used for?
E-64 is a potent, irreversible inhibitor of cysteine proteases, commonly used in research to study protease activity and cellular processes involving these enzymes.
What is the chemical formula and molecular weight of E-64?
The formula of E-64 is C15H27N5O5 with a molecular weight of 357.41 g/mol.
How should E-64 be stored?
E-64 should be stored at 2 to 8 °C to maintain stability and prevent degradation.
What grade of E-64 is available?
E-64 is available in research grade, suitable for laboratory use.
Can Molekula supply E-64 in bulk?
Yes, Molekula can supply E-64 in bulk quantities—please contact our sales team for pricing and availability.
What documentation comes with an E-64 order?
Each order includes a Certificate of Analysis (CoA) and safety data sheet (SDS) with the shipment.
Ready to order or need a custom pack?
Tell us the product, grade, and quantity — Molekula usually responds within one working day with pricing and lead time.