Molekula
BIS-TRIS (Bis(2-hydroxyethyl)amino-tris(hydroxymethyl)methane)
Supplying 4,500+ customers in over 80 countries
ISO 9001:2015 & ISO 14001:2015 certified · Supplying laboratories and industry since 2000 · Listed pack sizes are a starting point — we manufacture, source and repack to the quantity you need
BIS-TRIS is a buffering agent commonly used in biochemical and molecular biology applications, particularly in electrophoresis and enzyme assays. With a pKa of about 6.5 at 25 °C, it buffers effectively in the range of approximately pH 5.8 to 7.2. Available in powder form with a molecular weight of 209.24 g/mol, CAS number 6976-37-0, and molecular formula N(C2H4OH)2C(CH2OH)3. Store at ambient temperature. Signal word: Danger. Molekula supplies BIS-TRIS from research to bulk quantities with full documentation and ISO 9001:2015 traceability.
Example image for illustration only. Other packaging and pack sizes are available.
Often bought together
Pricing & pack sizes
These pack sizes aren't a limit. Molekula manufactures, sources and repacks to order — if you need 500 kg and only see 1 kg listed, . We quote from grams to multi-tonne.
Need a different size? Add the nearest pack and change the size in your basket — we price it at the same rate per unit.
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100 g — $88.40 per pack
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500 g — $236.60 per pack
Need a different quantity or pack?
Tell us how much you need and when — drums, IBCs, sacks or a one-off bulk lot. We'll manufacture or source it and come back with a price.
Prices exclude VAT/sales tax and shipping.
Specifications
| Property | Value |
|---|---|
| Appearance | White Crystalline Powder |
| Heavy metals | ≤10ppm |
| Identification | Conforms to reference |
| Loss on Drying | ≤1.0% |
| Residue on Ignition | ≤0.1% |
| pKa | 6.3-6.7 |
| Solubility (1M in H2O) | Clear and Complete |
| pH (1M in H2O) | 9.0-11.0 |
| Assay (Titration) on dried basis | ≥99.0% |
Storage & handling
| Property | Value |
|---|---|
| Storage Temperature | Ambient |
| Acidity | Base |
Identification
| Property | Value |
|---|---|
| SKU | 20228121 |
| CAS Number | 6976-37-0 |
| Molecular Formula | N(C2H4OH)2C(CH2OH)3 |
| Molecular Weight | 209.24 |
| SMILES | C(CO)N(CCO)C(CO)(CO)CO |
| REACH Code | Y110 |
| TSCA Listed | Yes |
| HTS Code | 2922.19.9619 |
| Tariff Code | 2922190090 |
Safety & GHS
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Corrosive
GHS05
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Health Hazard
GHS07
Hazard statements
- H315 Causes skin irritation
- H318 Causes serious eye damage
- H335 May cause respiratory irritation
Precautionary statements
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray
- P280 Wear protective gloves/protective clothing/eye protection/face protection
- P302+352 IF ON SKIN: Wash with soap and water
- P304+340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing
- P305+351+338 IF IN EYES: Rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing
- P308+313 IF exposed or concerned: Get medical advice/attention
Documents
Safety Data Sheets (SDS)
Available in English, French, German, Italian, Polish, Portuguese, Spanish.
Certificate of Analysis (CoA) by batch
Enter a lot or batch number to retrieve the CoA for that specific batch. We can generate one from spec data if no PDF is on file.
Synonyms
No alternate names recorded for this product.
Frequently asked questions
What is BIS-TRIS used for?
BIS-TRIS is primarily used as a buffering agent in biochemical and molecular biology applications, particularly in protein electrophoresis and enzyme assays.
What is the chemical formula and molecular weight of BIS-TRIS?
The formula is N(C2H4OH)2C(CH2OH)3 and the molecular weight is 209.24 g/mol.
How should BIS-TRIS be stored?
Store at ambient temperature, away from moisture and direct sunlight, as specified in the safety data sheet.
What grade of BIS-TRIS is available?
Molekula supplies BIS-TRIS in high-purity grade suitable for research and laboratory use.
Can Molekula supply BIS-TRIS in bulk?
Yes, Molekula can supply BIS-TRIS in bulk quantities—please contact our sales team for pricing and availability.
What documentation comes with a BIS-TRIS order?
Each order includes a Certificate of Analysis and Safety Data Sheet (SDS) with the shipment.
Ready to order or need a custom pack?
Tell us the product, grade, and quantity — Molekula usually responds within one working day with pricing and lead time.