Molekula
Aprepitant
Supplying 4,500+ customers in over 80 countries
ISO 9001:2015 & ISO 14001:2015 certified · Supplying laboratories and industry since 2000 · Listed pack sizes are a starting point — we manufacture, source and repack to the quantity you need
Aprepitant is a selective neurokinin-1 (NK1) receptor antagonist used primarily in antiemetic therapy to prevent chemotherapy-induced nausea and vomiting, as well as postoperative nausea. It is also approved for the prevention of delayed nausea and vomiting associated with highly emetogenic cancer therapy. Aprepitant has a CAS number of 170729-80-3, with the molecular formula C23H21F7N4O3 and a molecular weight of 534.43. It must be stored at -15 to -20°C and carries a signal word of Warning. Molekula supplies Aprepitant from research to bulk quantities with full documentation and ISO 9001:2015 traceability.
Example image for illustration only. Other packaging and pack sizes are available.
Pricing & pack sizes
These pack sizes aren't a limit. Molekula manufactures, sources and repacks to order — if you need 500 kg and only see 1 kg listed, . We quote from grams to multi-tonne.
Need a different size? Add the nearest pack and change the size in your basket — we price it at the same rate per unit.
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1 g — £123.90 per pack ex VAT · £148.68 inc. VAT
Need a different quantity or pack?
Tell us how much you need and when — drums, IBCs, sacks or a one-off bulk lot. We'll manufacture or source it and come back with a price.
Prices exclude VAT/sales tax and shipping.
Specifications
| Property | Value |
|---|---|
| Appearance | White or off-white crystalline powder |
| Impurity A | ≤0.15% |
| Specific rotation | +67° - +73° |
| Heavy metals | ≤0.001% |
| Impurity C | ≤0.1% |
| Loss on Drying | ≤0.5% |
| Assay | 98.0% - 102.0% |
| Methanol | ≤0.3% |
| Residue on Ignition | ≤0.1% |
| Total Impurities | ≤0.5% |
| Diethyl Ether | ≤0.5% |
Storage & handling
| Property | Value |
|---|---|
| Storage Temperature | -15 to -20 °C |
| Transport Class | 9 |
| Packing Group | III |
| Acidity | Neutral |
For research use only. Not for human use.
Identification
| Property | Value |
|---|---|
| SKU | 90028467 |
| CAS Number | 170729-80-3 |
| IUPAC Name | 3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,4-dihydro-1,2,4-triazol-5-one |
| Molecular Formula | C23H21F7N4O3 |
| Molecular Weight | 534.43 |
| Exact Mass | 534.1502 |
| SMILES | C[C@H](C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)O[C@@H]2[C@@H](N(CCO2)CC3=NNC(=O)N3)C4=CC=C(C=C4)F |
| InChIKey | ATALOFNDEOCMKK-OITMNORJSA-N |
| InChI | InChI=1S/C23H21F7N4O3/c1-12(14-8-15(22(25,26)27)10-16(9-14)23(28,29)30)37-20-19(13-2-4-17(24)5-3-13)34(6-7-36-20)11-18-31-21(35)33-32-18/h2-5,8-10,12,19-20H,6-7,11H2,1H3,(H2,31,32,33,35)/t12-,19+,20-/m1/s1 |
| PubChem CID | 135413536 |
| UN Number | UN3077 |
| REACH Code | Y110 |
| HTS Code | 2934.99.44.00 |
| Tariff Code | 2934999090 |
Safety & GHS
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Health Hazard
GHS07
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Serious Health Hazard
GHS08
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Hazardous to the Environment
GHS09
Hazard statements
- H302 Harmful if swallowed
- H319 Causes serious eye irritation
- H351 Suspected of causing cancer
- H361f Suspected of damaging fertility.
- H373 May cause damage to organs through prolonged or repeated exposure
- H400 Very toxic to aquatic life
Precautionary statements
- P201 Obtain special instructions before use
- P260 Do not breathe dust/fume/gas/mist/vapours/spray
- P273 Avoid release to the environment
- P280 Wear protective gloves/protective clothing/eye protection/face protection
- P305+351+338 IF IN EYES: Rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing
- P308+313 IF exposed or concerned: Get medical advice/attention
Documents
Safety Data Sheets (SDS)
Available in English, French, German, Italian, Portuguese, Spanish.
Certificate of Analysis (CoA) by batch
Enter a lot or batch number to retrieve the CoA for that specific batch. We can generate one from spec data if no PDF is on file.
Synonyms
- Aponvie
- Aprepitant (MK-0869)
- aprepitantum
- Cinvanti
- Emend
- Emend (TN)
- eMende
- L 754,030
- MK 0869
- MK 869
Frequently asked questions
What is aprepitant used for?
Aprepitant is primarily used as an antiemetic to prevent nausea and vomiting caused by chemotherapy, radiation therapy, and postoperative recovery.
What is the chemical formula and molecular weight of aprepitant?
The chemical formula is **C₂₃H₂₁F₇N₄O₃**, and the molecular weight is **534.43 g/mol**.
How should aprepitant be stored?
Aprepitant must be stored at **-15 to -20°C** to maintain stability and potency.
What grades or purity levels of aprepitant does Molekula supply?
Molekula supplies aprepitant in **pharmaceutical-grade purity**, suitable for clinical and research applications.
Can Molekula supply aprepitant in bulk quantities?
Yes, Molekula can provide aprepitant in bulk, with quantities tailored to meet customer requirements.
What documentation comes with an order of aprepitant?
Each order includes a **Certificate of Analysis (CoA)**, **Material Safety Data Sheet (MSDS)**, and **batch-specific documentation** for traceability.
Ready to order or need a custom pack?
Tell us the product, grade, and quantity — Molekula usually responds within one working day with pricing and lead time.