Molekula
4'-Chloroacetophenone
Supplying 4,500+ customers in over 80 countries
ISO 9001:2015 & ISO 14001:2015 certified · Supplying laboratories and industry since 2000 · Listed pack sizes are a starting point — we manufacture, source and repack to the quantity you need
4'-Chloroacetophenone is an aromatic ketone used as a synthetic building block in organic chemistry, for example in Claisen–Schmidt condensations to prepare chalcones and as a benchmark substrate in asymmetric ketone reduction to 1-(4-chlorophenyl)ethanol, as well as in polymer synthesis. It also serves as a chemical intermediate in the manufacture of pharmaceuticals. It is a colorless to pale yellow liquid at ambient temperature, melting at about 14–20 °C, with a sharp, pungent odor. Catalogue details: CAS 99-91-2, molecular formula ClC6H4COCH3, molecular weight 154.59 g/mol. Store at ambient temperature in a tightly sealed container, away from incompatible substances. Signal word: Danger. Molekula supplies 4'-Chloroacetophenone from research to bulk quantities with full documentation and ISO 9001:2015 traceability.
Example image for illustration only. Other packaging and pack sizes are available.
Pricing & pack sizes
These pack sizes aren't a limit. Molekula manufactures, sources and repacks to order — if you need 500 kg and only see 1 kg listed, . We quote from grams to multi-tonne.
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500 g — £102.70 per pack ex VAT · £123.24 inc. VAT
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Specifications
| Property | Value |
|---|---|
| Appearance | Colourless or Light yellow liquid |
| Assay/Purity | ≥99% (GC) |
| Boiling Point | 228-230℃ |
| Water | ≤0.5% |
Storage & handling
| Property | Value |
|---|---|
| Storage Temperature | Ambient |
| Flash Point | 90 °C |
| Transport Class | 6.1 |
| Packing Group | II |
| Acidity | Acid |
Literature values
Published physical properties of the substance, not batch specifications.
| Property | Value |
|---|---|
| Appearance | Liquid |
| Melting Point | 20-21 °C |
| Boiling Point | 237 °C |
| Vapour Pressure | 0.12 mmHg |
| Refractive Index | 1.5550 |
| log P (octanol/water) | 2.32 |
Source: PubChem CID 7467 (HSDB, Haz-Map)
Identification
| Property | Value |
|---|---|
| SKU | 43187122 |
| CAS Number | 99-91-2 |
| IUPAC Name | 1-(4-chlorophenyl)ethanone |
| EC Number | 202-800-7 |
| Molecular Formula | ClC6H4COCH3 |
| Molecular Weight | 154.59 |
| Exact Mass | 154.0185 |
| SMILES | CC(=O)C1=CC=C(C=C1)Cl |
| InChIKey | BUZYGTVTZYSBCU-UHFFFAOYSA-N |
| InChI | InChI=1S/C8H7ClO/c1-6(10)7-2-4-8(9)5-3-7/h2-5H,1H3 |
| PubChem CID | 7467 |
| UN Number | UN3416 |
| REACH Code | Y110 |
| TSCA Listed | Yes |
| Tariff Code | 2914790090 |
Safety & GHS
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Corrosive
GHS05
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Toxic
GHS06
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Health Hazard
GHS07
Hazard statements
- H302 Harmful if swallowed
- H315 Causes skin irritation
- H318 Causes serious eye damage
- H330 Fatal if inhaled
- H335 May cause respiratory irritation
- H412 Harmful to aquatic life with long lasting effects
Precautionary statements
- P260 Do not breathe dust/fume/gas/mist/vapours/spray
- P273 Avoid release to the environment
- P284 Wear respiratory protection
- P301+312 IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell
- P302+352 IF ON SKIN: Wash with soap and water
- P305+351+338 IF IN EYES: Rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing
Documents
Safety Data Sheets (SDS)
Available in English, French, German, Italian, Spanish.
Certificate of Analysis (CoA) by batch
Enter a lot or batch number to retrieve the CoA for that specific batch. We can generate one from spec data if no PDF is on file.
Synonyms
- 1-(4-Chlorophenyl)Ethan-1-One
- 1-(4-Chlorophenyl)ethanone
- 4-Acetylchlorobenzene
- Acetophenone, 4'-chloro-
- Ethanone, 1-(4-chlorophenyl)-
- Methyl p-chlorophenyl ketone
- p-Chloracetophenone
- P-CHLOROACETOPHENONE
- p-Chlorophenyl methyl ketone
- USAF DO-1
Frequently asked questions
What is 4'-Chloroacetophenone (CAS 99-91-2) commonly used for?
It is a ring-chlorinated acetophenone used as a synthetic building block and intermediate, for example in Claisen–Schmidt condensations to prepare chalcones and as a substrate in asymmetric ketone reduction. It is also used in organic synthesis as a reagent.
What is the chemical formula and molecular weight of 4'-Chloroacetophenone?
The formula is ClC₆H₄COCH₃, and the molecular weight is 154.59 g/mol.
How should 4'-Chloroacetophenone be stored?
Store in a cool, dry place at ambient temperature, away from incompatible substances (e.g., oxidizing agents, strong bases). Keep containers tightly sealed.
What purity grades or forms (solid/liquid) does Molekula supply for this product?
Molekula supplies technical grade (98%+ purity) as a colorless to pale yellow liquid at ambient temperature (it melts at about 14–20 °C). Higher purity or custom grades may be available upon request.
Can Molekula supply 4'-Chloroacetophenone in bulk quantities?
Yes, bulk quantities are available—contact our sales team for minimum order quantities (MOQs) and logistics details.
What documentation comes with an order of 4'-Chloroacetophenone?
Each order includes a Certificate of Analysis (CoA), Material Safety Data Sheet (MSDS/SDS), and batch-specific documentation for traceability. Custom packaging labels are also provided.
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