Molekula
L-(+)-Améthoptérine hydrate (Méthotréxate)
L-(+)-Amethopterin hydrate (Methotrexate)
L-(+)-Amethopterin hydrate, also known as Methotrexate, is a folic acid antagonist used in chemotherapy and autoimmune disease treatment. It inhibits dihydrofolate reductase, disrupting DNA synthesis. Available with CAS number 59-05-2, molecular formula C20H22N8O5, and molecular weight 454.44 g/mol. Stored at -15 to -20 °C. Signal word: Danger. Molekula supplies L-(+)-Amethopterin hydrate from research to bulk quantities with full documentation and ISO 9001:2015 traceability.
Aperçu
L-(+)-Amethopterin hydrate, also known as Methotrexate, is a folic acid antagonist used in chemotherapy and autoimmune disease treatment. It inhibits dihydrofolate reductase, disrupting DNA synthesis. Available with CAS number 59-05-2, molecular formula C20H22N8O5, and molecular weight 454.44 g/mol. Stored at -15 to -20 °C. Signal word: Danger. Molekula supplies L-(+)-Amethopterin hydrate from research to bulk quantities with full documentation and ISO 9001:2015 traceability.
Prix et formats de conditionnement
Spécifications
| Property | Value |
|---|---|
| Appearance | Yellow or orange crystalline, hygroscopic powder |
| Water | ≤ 13.0% |
| Impurity B | ≤ 0.3% |
| Heavy metals | ≤ 20ppm |
| Bacterial endotoxin | ≤ 0.1 EU/mg |
| Acetone | ≤ 1000 ppm |
| Impurity C | ≤ 0.5% |
| Solubility | Practically insolubile in water, in ethanol (96%) and in methylene chloride. It dissolves in dilute mineral acids and in dilute solutions od alkali hydroxides and carbonates |
| Assay | 98 - 102% |
| Sulphated Ash | ≤ 0.1% |
| Ethanol | ≤ 2000 ppm |
| Enantiomeric Purity | ≤ 3.0% |
| Identification (IR) | The IR spectrum of sample exhibits maxima only at the same wavelength as that a similar preparation of methotrexate CRS |
| Impurity E | ≤ 0.3% |
| Impurity H | ≤ 0.2% |
| Impurity I | ≤ 0.2% |
| Ethyl Ether | ≤ 500 ppm |
Stockage et manipulation
| Property | Value |
|---|---|
| Storage Temperature | -15 to -20 °C |
| Transport Class | 6.1 |
| Packing Group | III |
| Shelf Life | 24 months |
| Acidity | Base |
Identification
| Property | Value |
|---|---|
| SKU | 30186373 |
| CAS Number | 59-05-2 |
| Molecular Formula | C20H22N8O5 |
| Molecular Weight | 454.44 |
| SMILES | O=C(O)CCC(NC(=O)C1=CC=C(C=C1)N(C)CC=2N=C3C(=NC2)N=C(N=C3N)N)C(=O)O |
| EC / UN Number | 1544 |
| REACH Code | Y110 |
| TSCA Listed | Yes |
| HTS Code | 29335995 |
| Tariff Code | 2933599590 |
Sécurité et GHS
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Toxic
GHS06
-
Health Hazard
GHS07
-
Serious Health Hazard
GHS08
Déclarations de danger
- H301 Toxic if swallowed
- H315 Causes skin irritation
- H319 Causes serious eye irritation
- H335 May cause respiratory irritation
- H340 May cause genetic defects
- H360 May damage fertility or the unborn child
Déclarations de précaution
- P201 Obtain special instructions before use
- P280 Wear protective gloves/protective clothing/eye protection/face protection
- P301+310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician
- P302+352 IF ON SKIN: Wash with soap and water
- P304+340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing
- P305+351+338 IF IN EYES: Rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing
À usage recherche et industriel uniquement
Documents
Fiches de données de sécurité (FDS)
Disponible en IT, FR, ES, DE, EN.
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IT - (30186373) L-(+)-AMETHOPTERIN HYDRATE (METHOTREXATE) [59-05-2].pdf
SDS · IT · 251 KB
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FR - (30186373) L-(+)-AMETHOPTERIN HYDRATE (METHOTREXATE) [59-05-2].pdf
SDS · FR · 257 KB
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ES - (30186373) L-(+)-AMETHOPTERIN HYDRATE (METHOTREXATE) [59-05-2].pdf
SDS · ES · 255 KB
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DE - (30186373) L-(+)-AMETHOPTERIN HYDRATE (METHOTREXATE) [59-05-2].pdf
SDS · DE · 253 KB
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EN - (30186373) L-(+)-AMETHOPTERIN HYDRATE (METHOTREXATE) [59-05-2].pdf
SDS · EN · 250 KB
Certificat d'analyse (CoA) par lot
Saisissez un numéro de lot ou de série pour récupérer le certificat d'analyse correspondant à ce lot spécifique. Nous pouvons en générer un à partir des données de spécification si aucun PDF n'est disponible.
Synonymes
Aucun autre nom enregistré pour ce produit.
Questions fréquentes
What is L-(+)-Amethopterin hydrate used for?
It is primarily used as an antifolate drug in chemotherapy and autoimmune disease treatment, inhibiting dihydrofolate reductase.
What is the chemical formula and molecular weight of L-(+)-Amethopterin hydrate?
The formula is C20H22N8O5 with a molecular weight of 454.44 g/mol.
How should L-(+)-Amethopterin hydrate be stored?
It must be stored at -15 to -20 °C to maintain stability and prevent degradation.
What grade of L-(+)-Amethopterin hydrate does Molekula supply?
We supply it as a research-grade chemical, suitable for laboratory use.
Can Molekula supply L-(+)-Amethopterin hydrate in bulk?
Yes, we can provide bulk quantities—please contact our sales team for pricing and availability.
What documentation comes with an order of L-(+)-Amethopterin hydrate?
Each order includes a Certificate of Analysis (CoA) and Safety Data Sheet (SDS) with the shipment.
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Indiquez le produit, le grade et la quantité – Molekula répond généralement sous un jour ouvrable avec le prix et le délai de livraison.