Knowledge hub
Articles from the Molekula editorial team
Coverage of chemistry, regulatory updates, methods, supply-chain insight, and product spotlights. New articles published daily.
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Method-comparison
Optimising Cryoprotectant Formulations: Comparing Glycerol, DMSO and Ethylene Glycol Performance
Glycerol, DMSO and ethylene glycol are the most widely used cryoprotectants. Their effectiveness depends on concentration, cell type and cooling protocol; DMSO generally offers higher post‑thaw viability but greater toxicity, glycerol is less toxic but requires higher concentrations, and ethylene glycol provides a middle ground with rapid permeation.
Sep 23, 2026 · 4 min read -
Regulatory
Guidelines for Safe Transport of Bulk Peroxides under Updated ADR Regulations
Bulk peroxides must be transported in accordance with the 2023 ADR revisions, which reclassify them under Class 5.2, impose stricter packaging limits (up to 2 000 kg depending on Packaging Group), require temperature monitoring below 30 °C, and mandate detailed documentation and crew training.
Sep 21, 2026 · 4 min read -
Supplier-news
Evaluating the Resilience of African API Hubs After Recent Trade Disruptions
African active pharmaceutical ingredient (API) hubs have shown mixed resilience to recent trade disruptions. While some hubs have maintained output through local sourcing and inventory buffers, others face capacity constraints due to import delays, logistics bottlenecks and regulatory challenges, as highlighted by UNCTAD and Afreximbank analyses.
Sep 20, 2026 · 4 min read -
Supplier-news
Supplier qualification checklist for GMP‑grade isotopically labelled compounds in 2026
A robust supplier qualification checklist for GMP‑grade isotopically labelled compounds in 2026 must verify regulatory compliance (ISO 9001:2015, ISO 13485, GMP, REACH, TSCA), assess quality systems, confirm analytical capability (NMR, HPLC, GC‑MS), and evaluate documentation such as CoA, SDS and audit history.
Sep 19, 2026 · 4 min read -
Method
Implementing Real‑Time Impurity Monitoring for Nitrosamine‑Prone Intermediates Using PAT Tools
Real‑time impurity monitoring of nitrosamine‑prone intermediates can be achieved with PAT technologies such as inline HPLC, GC‑MS, and NIR, combined with AI‑driven data analytics. Key steps include selecting appropriate sensors, establishing calibration models, meeting USP and REACH limits, and integrating feedback control to keep nitrosamine levels below 0.5 ppm.
Aug 29, 2026 · 5 min read -
Method
Assessing Carbon‑Neutral Solvent Alternatives for Cross‑Coupling Reactions in Pharma Pipelines
Carbon‑neutral solvents such as 2‑methyltetrahydrofuran, cyclopentyl methyl ether and bio‑derived ethanol can replace traditional halogenated media in palladium‑catalysed cross‑couplings. They offer comparable yields (80‑95%), lower E‑factor, and align with REACH and ISO 14044 targets, provided process optimisation and impurity control are addressed.
Aug 28, 2026 · 5 min read -
Supplier-news
Strategic sourcing of rare earth catalysts amid geopolitical tensions in 2026
Rare earth catalysts remain essential for fine‑chemical and biopharmaceutical processes, but 2026 geopolitical tensions have tightened supply chains. China still supplies the majority, while export controls and trade disputes increase lead times and price volatility. Diversified sourcing, recycling, and alternative chemistries are the primary risk‑mitigation strategies.
Aug 27, 2026 · 4 min read -
Regulatory
Navigating US Inflation Reduction Act Incentives for Domestic API Manufacturing Supplies
The Inflation Reduction Act (IRA) offers US API manufacturers a domestic‑content tax credit of up to 30% of qualified investment, subject to a $7,500 per employee cap and a minimum 40% domestic‑content threshold. Eligibility hinges on detailed documentation, timing of asset placement, and compliance with IRS and Treasury guidance.
Aug 26, 2026 · 6 min read -
Regulatory
Emerging REACH SVHC Additions in 2026: Impact on Organophosphorus Reagents
From 1 June 2026 the EU REACH candidate list will include three new surface‑treatment agents and five additional substances, several of which are organophosphorus intermediates. These additions trigger registration, communication and possible restriction obligations for manufacturers and users of organophosphorus reagents.
Aug 25, 2026 · 5 min read -
Supplier-news
Buffer and Reducing‑Agent Supply (DTT/TCEP/HEPES/Tris): Sourcing and Quality in 2026
In 2026, DTT and TCEP remain the principal disulphide‑reducing agents, with TCEP offering greater pH stability and longer shelf‑life, while DTT is cheaper but oxidises rapidly. HEPES and Tris buffers are widely available from multiple GMP‑certified manufacturers, with purity specifications of ≥99.5 % and consistent ISO‑9001 compliance. Regulatory frameworks (REACH, USP, EP) continue to dictate documentation and testing requirements.
Aug 24, 2026 · 5 min read -
Supplier-news
Biocatalysis and Enzyme Engineering in Pharma Synthesis: What Is Changing Procurement?
Biocatalysis and enzyme engineering are reshaping pharmaceutical manufacturing, prompting procurement teams to prioritise supplier reliability, regulatory compliance, and sustainability. Procurement now evaluates enzyme activity data, batch‑to‑batch consistency, and life‑cycle impact, while negotiating flexible contracts to accommodate rapid process optimisation.
Aug 23, 2026 · 4 min read -
Supplier-news
Semiconductor‑grade chemical shortages and their knock‑on effects for high‑purity reagents
The semiconductor industry is experiencing a shortage of high‑purity, semiconductor‑grade chemicals due to heightened demand and limited production capacity. This scarcity cascades into biotech and pharmaceutical labs, restricting access to critical reagents and prompting supply‑chain adjustments.
Aug 21, 2026 · 3 min read