Knowledge hub
Articles from the Molekula editorial team
Coverage of chemistry, regulatory updates, methods, supply-chain insight, and product spotlights. New articles published daily.
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Regulatory
Supply‑chain risk assessment of manganese‑based catalysts after recent export controls
Recent export controls on manganese compounds have introduced significant uncertainty for manufacturers relying on manganese‑based catalysts. Key risks include reduced availability, price volatility, longer lead times and the need for alternative sourcing strategies, all of which require proactive assessment and mitigation.
Oct 5, 2026 · 5 min read -
Method
Green synthesis of heterocyclic scaffolds using bio‑derived solvents: a buyer’s guide
Bio‑derived solvents such as 2‑methyltetrahydrofuran, cyclopentyl methyl ether and ethyl lactate enable greener routes to heterocyclic scaffolds, offering lower toxicity, reduced VOC emissions and comparable yields to conventional solvents. Selecting the right solvent requires balancing polarity, boiling point, recyclability and regulatory status.
Oct 4, 2026 · 6 min read -
Applications
Evaluating blockchain for traceability of critical API intermediates in 2026
Blockchain offers an immutable, decentralised ledger that can record each transaction of API intermediates, providing real‑time visibility, tamper‑proof audit trails and automated compliance checks. In 2026, its adoption hinges on integration with existing ERP systems, regulatory acceptance and demonstrable cost‑benefit over legacy traceability methods.
Oct 3, 2026 · 5 min read -
Supplier-news
Sourcing High‑Purity Rare Isotopes for Radiopharmaceuticals Amid Global Shortages
High‑purity rare isotopes for radiopharmaceuticals can still be sourced despite worldwide shortages by diversifying suppliers, using alternative production routes, and implementing strict quality‑control protocols. Key actions include engaging multiple certified manufacturers, verifying ISO/REACH compliance, and maintaining a validated inventory management system.
Oct 2, 2026 · 5 min read -
Regulatory
Impact of US EPA PFAS Phase‑out on Fluorinated Polymer Sourcing for Biotech
The US EPA’s PFAS phase‑out, announced in 2024, restricts production and use of long‑chain per‑ and poly‑fluoroalkyl substances, directly influencing the availability, cost and compliance requirements of fluorinated polymers used in biotech. Suppliers must adapt sourcing strategies, validate alternatives and manage regulatory documentation.
Oct 1, 2026 · 4 min read -
Regulatory
Adapting GHS Labelling for Nanomaterial Reagents under the 2026 Regulatory Updates
The 2026 GHS revision introduces specific provisions for nanomaterials, requiring updated hazard classifications, new pictograms, and expanded SDS sections. Laboratories must revise labelling, incorporate nano‑specific exposure limits, and ensure compliance with UNECE Rev. 11, while maintaining alignment with OSHA and PubChem guidance.
Sep 30, 2026 · 5 min read -
Regulatory
Regulatory pathways for novel peptide‑drug conjugates under updated FDA CMC guidance
The FDA’s revised CMC guidance for peptide‑drug products clarifies classification, data requirements and submission timelines for novel peptide‑drug conjugates (PDCs). It defines the CMC dossier contents, analytical expectations and post‑approval obligations, enabling sponsors to align IND, NDA and BLA strategies with current regulatory expectations.
Sep 29, 2026 · 5 min read -
Method-comparison
Economic analysis of on‑site versus outsourced production of specialty amino acids
On‑site production of specialty amino acids requires substantial capital investment and ongoing operational costs, while outsourcing converts fixed costs into variable fees and reduces supply‑chain risk. The choice hinges on scale, product value, regulatory burden and long‑term strategic goals.
Sep 28, 2026 · 4 min read -
Method
Choosing the right fluorinated surfactant for microfluidic chip fabrication in 2026
Selecting a fluorinated surfactant for microfluidic chips in 2026 requires balancing droplet stability, biocompatibility, and regulatory compliance. Key factors include HLB value, fluorocarbon chain length, and the presence of functional end‑groups; recent literature highlights perfluoro‑octyl‑polyethylene glycol (PF‑OPEG) and fluorinated block copolymers as leading options.
Sep 27, 2026 · 5 min read -
Method
Best practices for validating high‑throughput LC‑MS methods for impurity profiling
High‑throughput LC‑MS impurity profiling requires systematic validation of accuracy, precision, linearity, limits of detection, and system suitability. Follow ICH Q2(R1) criteria, use cross‑validation with orthogonal techniques, and document all parameters to ensure reproducible, regulatory‑compliant results.
Sep 26, 2026 · 4 min read -
Regulatory
Impact of the EU’s 2026 Green Chemistry Taxonomy on Solvent Procurement Strategies
The EU’s 2026 Green Chemistry Taxonomy will classify solvents based on sustainability criteria such as toxicity, renewable feedstock and energy efficiency. Procurement teams must align purchasing, documentation and reporting with the taxonomy’s technical screening criteria to maintain compliance and access sustainable‑finance incentives.
Sep 25, 2026 · 5 min read -
Method
Lifecycle Assessment of Biodegradable Polymers for Single‑Use Bioprocessing Equipment
Biodegradable polymers such as polylactide (PLA) and polyhydroxyalkanoates (PHA) can lower the environmental impact of single‑use bioprocessing equipment. Lifecycle assessments show reductions of up to 30 % in global warming potential and significant waste‑diversion benefits, provided appropriate disposal pathways are used.
Sep 24, 2026 · 4 min read