Molekula
L-(+)-Amethopterin hydrate (Methotrexate)
L-(+)-Amethopterin hydrate, also known as Methotrexate, is a folic acid antagonist used in chemotherapy and autoimmune disease treatment. It inhibits dihydrofolate reductase, disrupting DNA synthesis. Available with CAS number 59-05-2, molecular formula C20H22N8O5, and molecular weight 454.44 g/mol. Stored at -15 to -20 °C. Signal word: Danger. Molekula supplies L-(+)-Amethopterin hydrate from research to bulk quantities with full documentation and ISO 9001:2015 traceability.
Overview
L-(+)-Amethopterin hydrate, also known as Methotrexate, is a folic acid antagonist used in chemotherapy and autoimmune disease treatment. It inhibits dihydrofolate reductase, disrupting DNA synthesis. Available with CAS number 59-05-2, molecular formula C20H22N8O5, and molecular weight 454.44 g/mol. Stored at -15 to -20 °C. Signal word: Danger. Molekula supplies L-(+)-Amethopterin hydrate from research to bulk quantities with full documentation and ISO 9001:2015 traceability.
Specifications
| Property | Value |
|---|---|
| Appearance | Yellow or orange crystalline, hygroscopic powder |
| Water | ≤ 13.0% |
| Impurity B | ≤ 0.3% |
| Heavy metals | ≤ 20ppm |
| Bacterial endotoxin | ≤ 0.1 EU/mg |
| Acetone | ≤ 1000 ppm |
| Impurity C | ≤ 0.5% |
| Solubility | Practically insolubile in water, in ethanol (96%) and in methylene chloride. It dissolves in dilute mineral acids and in dilute solutions od alkali hydroxides and carbonates |
| Assay | 98 - 102% |
| Sulphated Ash | ≤ 0.1% |
| Ethanol | ≤ 2000 ppm |
| Enantiomeric Purity | ≤ 3.0% |
| Identification (IR) | The IR spectrum of sample exhibits maxima only at the same wavelength as that a similar preparation of methotrexate CRS |
| Impurity E | ≤ 0.3% |
| Impurity H | ≤ 0.2% |
| Impurity I | ≤ 0.2% |
| Ethyl Ether | ≤ 500 ppm |
Storage & handling
| Property | Value |
|---|---|
| Storage Temperature | -15 to -20 °C |
| Transport Class | 6.1 |
| Packing Group | III |
| Shelf Life | 24 months |
| Acidity | Base |
Identification
| Property | Value |
|---|---|
| CAS Number | 59-05-2 |
| Molecular Formula | C20H22N8O5 |
| Molecular Weight | 454.44 |
| SMILES | O=C(O)CCC(NC(=O)C1=CC=C(C=C1)N(C)CC=2N=C3C(=NC2)N=C(N=C3N)N)C(=O)O |
| EC / UN Number | 1544 |
| REACH Code | Y110 |
| TSCA Listed | Yes |
| HTS Code | 29335995 |
| Tariff Code | 2933599590 |
Safety & GHS
-
Explosive
GHS01
-
Flammable
GHS02
-
Corrosive
GHS05
Hazard statements
- H301 Toxic if swallowed
- H315 Causes skin irritation
- H319 Causes serious eye irritation
- H335 May cause respiratory irritation
- H340 May cause genetic defects
- H360 May damage fertility or the unborn child
Precautionary statements
- P201 Obtain special instructions before use
- P280 Wear protective gloves/protective clothing/eye protection/face protection
- P301+310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician
- P302+352 IF ON SKIN: Wash with soap and water
- P304+340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing
- P305+351+338 IF IN EYES: Rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing
For research and industrial use only
Documents
Certificate of Analysis (CoA) by batch
Enter a lot or batch number to retrieve the CoA for that specific batch. We can generate one from spec data if no PDF is on file.
Pricing & pack sizes
Synonyms
No alternate names recorded for this product.
Frequently asked questions
What is L-(+)-Amethopterin hydrate used for?
It is primarily used as an antifolate drug in chemotherapy and autoimmune disease treatment, inhibiting dihydrofolate reductase.
What is the chemical formula and molecular weight of L-(+)-Amethopterin hydrate?
The formula is C20H22N8O5 with a molecular weight of 454.44 g/mol.
How should L-(+)-Amethopterin hydrate be stored?
It must be stored at -15 to -20 °C to maintain stability and prevent degradation.
What grade of L-(+)-Amethopterin hydrate does Molekula supply?
We supply it as a research-grade chemical, suitable for laboratory use.
Can Molekula supply L-(+)-Amethopterin hydrate in bulk?
Yes, we can provide bulk quantities—please contact our sales team for pricing and availability.
What documentation comes with an order of L-(+)-Amethopterin hydrate?
Each order includes a Certificate of Analysis (CoA) and Safety Data Sheet (SDS) with the shipment.
Ready to order or need a custom pack?
Tell us the product, grade, and quantity — Molekula usually responds within one working day with pricing and lead time.