Applicazione
Solid-phase peptide synthesis
Coupling reagents, protected amino acids, and cleavage cocktails for Fmoc and Boc SPPS.
Solid-phase peptide synthesis (SPPS) attaches Fmoc- or Boc-protected amino acids to a resin one at a time. Each cycle deprotects, activates with a coupling reagent (HATU, HBTU, PyBOP), and adds the next residue. Final cleavage with TFA + scavengers releases the peptide. Molekula supplies HATU, HBTU, DIPEA, piperidine, TFA and DMF in research and process-chemistry quantities.
Cosa è incluso in questo flusso di lavoro
- Coupling reagents
- HATU, HBTU, PyBOP, DIC, EDC·HCl — choose by sterics, racemization risk, and cost.
- Bases
- DIPEA (Hünig's base), NMM, TMP.
- Solvents
- DMF, NMP, DCM — high-purity, low-amine.
- Deprotection & cleavage
- Piperidine (Fmoc removal), TFA + scavengers (TIS, water, EDT).
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FAQ
Which coupling reagent has the lowest racemization risk?
HATU is generally lowest-racemization, followed by HBTU/PyBOP. DIC/HOBt is cheaper for non-sensitive couplings.
What scavenger cocktail should I use for TFA cleavage?
A standard "Reagent K" cocktail is TFA/phenol/water/thioanisole/EDT 82.5/5/5/5/2.5 (v/v). Adjust for cysteine, methionine, tryptophan or serine-heavy sequences.
Does Molekula supply Fmoc-protected amino acids?
Some standard residues are stocked; rare derivatives and unnatural amino acids are made-to-order. Use the quote button or contact us with your sequence.
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