CAS Registry Number

CAS 136849-72-4 — O-((Ethoxycarbonyl)cyanomethylenamino)-N,N,NN-tetramethyluronium tetrafluoroborate (TOTU)

O-((Ethoxycarbonyl)cyanomethylenamino)-N,N,NN-tetramethyluronium tetrafluoroborate (TOTU) is a highly efficient coupling reagent used in peptide synthesis to activate carboxylic acids for amide bond formation, minimizing racemization and improving yields. It is particularly valued in solid-phase peptide synthesis (SPPS) for its mild reaction conditions and compatibility with sensitive functional groups. This reagent has a CAS number of 136849-72-4, with a molecular formula of C10H17BF4N4O3 and a molecular weight of 328.0716 g/mol. It is stable under ambient storage conditions and carries no signal word for hazard classification. Molekula supplies TOTU from research to bulk quantities with full documentation and ISO 9001:2015 traceability.