Molekula
TRIS (Tris(hydroxymethyl)aminomethane) ≥ 99.9%
ISO 9001:2015 & ISO 14001:2015 certified · Supplying laboratories and industry since 2000 · Certificate of Analysis with every batch
TRIS (Tris(hydroxymethyl)aminomethane) is a widely used buffering agent and pH stabilizer in biochemical, pharmaceutical, and molecular biology applications, including cell culture media, protein purification, and DNA/RNA research. It is also employed in electrophoresis and as a standard in biochemical assays due to its buffering capacity near physiological pH. This high-purity TRIS (≥ 99.9%) has a CAS number of 77-86-1, molecular formula NH2C(CH2OH)3, and a molecular weight of 121.14. It is stored at ambient conditions, with a signal word of Warning for safety classification. Molekula supplies TRIS from research to bulk quantities with full documentation and ISO 9001:2015 traceability.
Overview
TRIS (Tris(hydroxymethyl)aminomethane) is a widely used buffering agent and pH stabilizer in biochemical, pharmaceutical, and molecular biology applications, including cell culture media, protein purification, and DNA/RNA research. It is also employed in electrophoresis and as a standard in biochemical assays due to its buffering capacity near physiological pH. This high-purity TRIS (≥ 99.9%) has a CAS number of 77-86-1, molecular formula NH2C(CH2OH)3, and a molecular weight of 121.14. It is stored at ambient conditions, with a signal word of Warning for safety classification. Molekula supplies TRIS from research to bulk quantities with full documentation and ISO 9001:2015 traceability.
Pricing & pack sizes
Specifications
| Property | Value |
|---|---|
| Appearance | White crystalline powder |
| Assay/Purity | 99.9 - 101.1 % |
| Melting Point | 168 - 172°C |
| Conclusion | Conforms to standard |
| pH | 10.0 to 11.5 (5% aq.) |
| Loss on Drying | ≤ 0.1% |
| UV Absorbance | A (250nm, 1M, 1cm) ≤ 0.25 Abs unit. A (290nm, 40 %, 1cm) ≤ 0.05 Abs unit. |
| Residue on Ignition | ≤ 0.1% |
| Cadmium (Cd) | ≤ 1ppm |
| Iron (Fe) | ≤ 1ppm |
| Water (KF) | ≤ 1.0 % |
| Lead (Pb) | ≤ 1ppm |
| Identification (IR) | Conforms to Reference |
| Arsenic (As) | ≤ 1ppm |
| Calcium (Ca) | ≤ 1ppm |
| Copper (Cu) | ≤ 1ppm |
| Magnesium (Mg) | ≤ 1ppm |
| pKa 20°C | 8.30 ± 0.15 |
| Barium (Ba) | ≤ 1ppm |
| Zinc (Zn) | ≤ 1ppm |
| Manganese (Mn) | ≤ 1ppm |
| Solubility (40% aqueous) | Clear, colourless solution |
Storage & handling
| Property | Value |
|---|---|
| Storage Temperature | Ambient |
| Acidity | Base |
Identification
| Property | Value |
|---|---|
| SKU | 90036521 |
| CAS Number | 77-86-1 |
| Molecular Formula | NH2C(CH2OH)3 |
| Molecular Weight | 121.14 |
| SMILES | C(C(CO)(CO)N)O |
| REACH Code | Y113 |
| TSCA Listed | Yes |
| HTS Code | 29221996 |
| Tariff Code | 2922190090 |
Safety & GHS
-
Health Hazard
GHS07
Hazard statements
- H315 Causes skin irritation
- H319 Causes serious eye irritation
- H335 May cause respiratory irritation
Precautionary statements
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray
- P280 Wear protective gloves/protective clothing/eye protection/face protection
- P305+351+338 IF IN EYES: Rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing
- P308+313 IF exposed or concerned: Get medical advice/attention
Documents
Safety Data Sheets (SDS)
Available in English, French, German, Italian, Portuguese, Spanish.
Certificate of Analysis (CoA) by batch
Enter a lot or batch number to retrieve the CoA for that specific batch. We can generate one from spec data if no PDF is on file.
Synonyms
No alternate names recorded for this product.
Frequently asked questions
What is Tris(hydroxymethyl)aminomethane (TRIS) commonly used for?
TRIS is widely used as a buffer in molecular biology (e.g., DNA/protein experiments), biochemistry, and pharmaceutical formulations due to its stable pH across a range of temperatures.
What is the chemical formula and molecular weight of this TRIS?
The formula is **NH₂C(CH₂OH)₃** with a molecular weight of **121.14 g/mol** (CAS 77-86-1).
What is the hazard classification (signal word) for this TRIS?
The signal word is **Warning**, indicating moderate hazard (e.g., eye irritation, skin contact risks). Full SDS is provided with orders.
How should this TRIS be stored?
Store at **ambient conditions** in a tightly sealed container, away from strong oxidizers or acids to prevent degradation.
Does Molekula offer this TRIS in bulk quantities?
Yes, we supply **≥99.9% TRIS in bulk** (minimum order quantities vary; contact sales for custom packaging options).
What documentation comes with a TRIS order?
Each order includes a **Certificate of Analysis (CoA)**, Safety Data Sheet (SDS), and batch-specific documentation for traceability.
Ready to order or need a custom pack?
Tell us the product, grade, and quantity — Molekula usually responds within one working day with pricing and lead time.